Association between endometriosis and risk of type 2 diabetes: Results from the prospective E3N cohort

• Published in: Maturitas Vol. 177; p. 107805
• Main Authors: Vaduva, Patricia, Laouali, Nasser, Fagherazzi, Guy, Gelot, Amandine, Bonnet, Fabrice, Kvaskoff, Marina
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.11.2023; Elsevier
• Subjects: Endometriosis; Epidemiology; Incidence; Life Sciences; Type 2 diabetes; Type 2 diabetes; Endometriosis; Epidemiology; Incidence; Endometriosis; Epidemiology; Incidence; Type 2 diabetes
• ISSN: 0378-5122; 1873-4111
• DOI: 10.1016/j.maturitas.2023.107805

•Endometriosis has been associated with several cardio-metabolic diseases.•In our prospective cohort of 98,995 French women, endometriosis was not associated with type 2 diabetes.•The association was not modified by age, lifestyle or reproductive factors. Several studies suggest an association between endometriosis and the risk of cardio-metabolic diseases. This study aimed to prospectively evaluate the association between history of endometriosis and incident type 2 diabetes. E3N is a prospective cohort of 98,995 French women aged 40–65 years at inclusion. Multivariable Cox regression models were used to estimate hazard ratios and 95 % confidence intervals for the association between endometriosis and incident type 2 diabetes. We evaluated effect modification by age, body mass index, infertility treatment, adherence to the Mediterranean diet, and menopausal status. Age at inclusion was 51 ± 6 years and there were 2672 incident cases of type 2 diabetes. A total of 4606 women reported surgically-confirmed endometriosis among 83,582 women with no history of diabetes at inclusion. Endometriosis was not associated with type 2 diabetes risk in a model adjusted for age, BMI, physical activity, smoking, education, age at menarche and oral contraceptive use (hazard ratio [HR] = 1.09; 95 % confidence interval [CI] = 0.92–1.29), neither after further adjustment for family history of diabetes, hypertension and menopausal status (HR = 0.97;95%CI = 0.80–1.16). The relationship did not differ by age at inclusion, BMI, infertility treatment, diet or menopausal status (p > 0.05). Surgically-confirmed endometriosis was not associated with the risk of type 2 diabetes in this large cohort, confirming that endometriosis is not a risk marker for type 2 diabetes.