Magnetic resonance morphometry of the loss of gray matter volume in Parkinson’s disease patients

• Published in: Neural regeneration research Vol. 8; no. 27; pp. 2557 - 2565
• Main Authors: Xia, Jianguo, Wang, Juan, Tian, Weizhong, Ding, Hongbin, Wei, Qilin, Huang, Huanxin, Wang, Jun, Zhao, Jinli, Gu, Hongmei, Tang, Lemin
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 25.09.2013; Department of Radiology, Taizhou People’s Hospital of Nantong University, Nantong 225300, Jiangsu Province, China%Department of Medical Image Engineering, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China%Department of Geriatrics, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China%Department of Radiology, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province, China; Medknow Publications & Media Pvt Ltd
• Subjects: Care and treatment; Diagnosis; Magnetic resonance imaging; Morphometrics (Biology); Parkinson's disease; Patient outcomes; Research and Report : Neurodegenerative Disease and Neural Regeneration; 体积; 定量评估; 帕金森病; 形态计量学; 患者; 损失; 灰质; 磁共振; Parkinson's disease; neurodegenerative disease; Montreal Cognitive Assessment; MRI; neurodegeneration; gray matter abnormality; voxel-based morphometry; non-motor symptoms; neuroimaging; neural regeneration; neuroregeneration; grants-supported paper; region of interest; Mini-Mental State Examination; dopamine
• ISSN: 1673-5374; 1876-7958
• DOI: 10.3969/j.issn.1673-5374.2013.27.007

Voxel-based morphometry can be used to quantitatively compare structural differences and func-tional changes of gray matter in subjects. In the present study, we compared gray matter images of 32 patients with Parkinson’s disease and 25 healthy controls using voxel-based morphometry based on 3.0 T high-field magnetic resonance T1-weighted imaging and clinical neurological scale scores. Results showed that the scores in Mini-Mental State Examination and Montreal Cognitive Assessment were lower in patients compared with controls. In particular, the scores of visuospatial/executive function items in Montreal Cognitive Assessment were significantly reduced, but mean scores of non-motor symptoms significantly increased, in patients with Parkinson’s dis-ease. In addition, gray matter volume was significantly diminished in Parkinson’s disease patients compared with normal controls, including bilateral temporal lobe, bilateral occipital lobe, bilateral parietal lobe, bilateral frontal lobe, bilateral insular lobe, bilateral parahippocampal gyrus, bilateral amygdale, right uncus, and right posterior lobe of the cerebel um. These findings indicate that voxel-based morphometry can accurately and quantitatively assess the loss of gray matter volume in patients with Parkinson＇s disease, and provide essential neuroimaging evidence for multisystem pathological mechanisms involved in Parkinson’s disease.