Reductive biotransformation of diethyl β-, γ- and δ-oxoalkylphosphonates by cells of baker’s yeast

Enantiomerically pure hydroxyalkylphosphonates (over 95% of enantiomeric excess) were obtained by asymmetric reductive biotransformation of a variety of oxoalkylphosphonates catalyzed by baker’s yeast. In the most cases the biotransformations were carried out in water under aerobic conditions using...

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Bibliographic Details
Published inEnzyme and microbial technology Vol. 26; no. 2; pp. 265 - 270
Main Authors Żymańczyk–Duda, Ewa, Kafarski, Pawel, Lejczak, Barbara
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier Inc 01.02.2000
Elsevier Science
Subjects
Baker’s yeast
Bioconversions. Hemisynthesis
Biological and medical sciences
Biosynthesis
Biotechnology
Biotransformation
Catalyst activity
Diethyl hydroxyphosphonates
Diethyl ketophosphonates
diethyl oxoalkylphosphonates
Enantioselective reduction
Fatty acids
Fundamental and applied biological sciences. Psychology
hydroxyalkylphosphonic acids
Methods. Procedures. Technologies
Reduction
Saccharomyces cerevisiae
Yeast
Diethyl ketophosphonates
Baker’s yeast
Diethyl hydroxyphosphonates
Biotransformation
Enantioselective reduction
Reduction
Baker yeast
Organic phosphonate
Ketoester
Enantioselectivity
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Summary:Enantiomerically pure hydroxyalkylphosphonates (over 95% of enantiomeric excess) were obtained by asymmetric reductive biotransformation of a variety of oxoalkylphosphonates catalyzed by baker’s yeast. In the most cases the biotransformations were carried out in water under aerobic conditions using whole cell system. In the case of compounds unreactive under these conditions the anaerobic reduction was applied.
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ISSN:0141-0229
1879-0909
DOI:10.1016/S0141-0229(99)00159-3