Caveolin‐1, cancer and therapy resistance

• Published in: International journal of cancer Vol. 143; no. 9; pp. 2092 - 2104
• Main Authors: Ketteler, Julia, Klein, Diana
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2018
• Subjects: Cancer; Cancer therapies; Caveolin; Caveolin-1; Cell survival; chemotherapy; Medical research; Membrane proteins; Metastases; Metastasis; Phenotypes; Radiation; Radiation therapy; Solid tumors; Stroma; therapy resistance; tumor microenvironment; Tumors; caveolin-1; cancer; tumor microenvironment; radiation; chemotherapy; therapy resistance

Resistance of solid tumors to chemo‐ and radiotherapy remains a major obstacle in anti‐cancer treatment. Herein, the membrane protein caveolin‐1 (CAV1) came into focus as it is highly expressed in many tumors and high CAV1 levels were correlated with tumor progression, invasion and metastasis, and t...