Caveolin‐1, cancer and therapy resistance

Resistance of solid tumors to chemo‐ and radiotherapy remains a major obstacle in anti‐cancer treatment. Herein, the membrane protein caveolin‐1 (CAV1) came into focus as it is highly expressed in many tumors and high CAV1 levels were correlated with tumor progression, invasion and metastasis, and t...

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Bibliographic Details
Published inInternational journal of cancer Vol. 143; no. 9; pp. 2092 - 2104
Main Authors Ketteler, Julia, Klein, Diana
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.11.2018
Subjects
Cancer
Cancer therapies
Caveolin
Caveolin-1
Cell survival
chemotherapy
Medical research
Membrane proteins
Metastases
Metastasis
Phenotypes
Radiation
Radiation therapy
Solid tumors
Stroma
therapy resistance
tumor microenvironment
Tumors
caveolin-1
cancer
tumor microenvironment
radiation
chemotherapy
therapy resistance
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Summary:Resistance of solid tumors to chemo‐ and radiotherapy remains a major obstacle in anti‐cancer treatment. Herein, the membrane protein caveolin‐1 (CAV1) came into focus as it is highly expressed in many tumors and high CAV1 levels were correlated with tumor progression, invasion and metastasis, and thus a worse clinical outcome. Increasing evidence further indicates that the heterogeneous tumor microenvironment, also known as the tumor stroma, contributes to therapy resistance resulting in poor clinical outcome. Again, CAV1 seems to play an important role in modulating tumor host interactions by promoting tumor growth, metastasis, therapy resistance and cell survival. However, the mechanisms driving stroma‐mediated tumor growth and radiation resistance remain to be clarified. Understanding these interactions and thus, targeting CAV1 may offer a novel strategy for preventing cancer therapy resistance and improving clinical outcomes. In this review, we will summarize the resistance‐promoting effects of CAV1 in tumors, and emphasize its role in the tumor‐stroma communication as well as the resulting malignant phenotype of epithelial tumors.
Bibliography:Conflict of interest
The authors state that there are no personal or institutional conflict of interest.
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ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.31369