Matching donor and recipient based on predicted indirectly recognizable human leucocyte antigen epitopes

Summary The predicted indirectly recognizable human leucocyte antigen (HLA) epitopes (PIRCHE) algorithm is a novel in silico algorithm to determine donor–recipient compatibility. The PIRCHE algorithm determines donor–recipient compatibility by counting the number of mismatched HLA‐derived epitopes t...

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Bibliographic Details
Published inInternational journal of immunogenetics Vol. 45; no. 2; pp. 41 - 53
Main Authors Geneugelijk, K., Spierings, E.
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.04.2018
Subjects
Algorithms
Antigens
Epitopes
Hematopoietic stem cells
histocompatibility
Histocompatibility antigen HLA
human leucocyte antigen
Lymphocytes T
matching
PIRCHE
Stem cell transplantation
transplantation
epitopes
PIRCHE
histocompatibility
human leucocyte antigen
transplantation
matching
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Summary:Summary The predicted indirectly recognizable human leucocyte antigen (HLA) epitopes (PIRCHE) algorithm is a novel in silico algorithm to determine donor–recipient compatibility. The PIRCHE algorithm determines donor–recipient compatibility by counting the number of mismatched HLA‐derived epitopes that are involved in indirect T‐cell alloimmune responses; these epitopes are designated as PIRCHE. Over the last few years, the PIRCHE algorithm has been investigated in both hematopoietic stem cell transplantation and solid organ transplantation. This review describes the theory of the algorithm, its application in transplantation, and highlights the future perspectives on the clinical application of the PIRCHE algorithm.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1744-3121
1744-313X
DOI:10.1111/iji.12359