ZZ domains keep cytosol to vacuole delivery whiZZing along

Selective autophagy relies on adaptor proteins to bind and transport cargos (or substrates) to the lysosome or vacuole, yet the mechanisms for cargo recognition are not well understood. In this issue, Wang et al (2021) showed that in the fission yeast, Nbr1, a homolog of a mammalian selective autoph...

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Bibliographic Details
Published inThe EMBO journal Vol. 40; no. 15; pp. e108777 - n/a
Main Authors Hama, Yutaro, Zhang, Sidi, Mizushima, Noboru
Format Journal Article
LanguageEnglish
Published Heidelberg Blackwell Publishing Ltd 02.08.2021
John Wiley and Sons Inc
Subjects
Adaptor proteins
Autophagy
Cargo
Cytosol
Domains
Homology
Phagocytosis
Protein transport
Substrates
Views
Yeasts
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Summary:Selective autophagy relies on adaptor proteins to bind and transport cargos (or substrates) to the lysosome or vacuole, yet the mechanisms for cargo recognition are not well understood. In this issue, Wang et al (2021) showed that in the fission yeast, Nbr1, a homolog of a mammalian selective autophagy adaptor, recognizes vacuolar hydrolases Ams1 and Ape4 through both versatile and cargo‐specific interactions with the Nbr1 ZZ1 domain. A recent study identifies two novel substrates for Schizosaccharomyces pombe Nrb1 intracellular cargo adaptor and uncovers their recognition mechanism by Nbr1's ZZ1 domain.
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See also: YY Wang et al (August 2021)
ISSN:0261-4189
1460-2075
DOI:10.15252/embj.2021108777