A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

Azadirachta indica L. is a multipurpose medicinal tree of family Meliaceae. It occurs in tropical and semitropical regions of the world. Different parts of this miraculous tree are used to treat pyrexia, headache, ulcer, respiratory disorders, cancer, diabetes, leprosy, malaria, dengue, chicken pox,...

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Published inPhytotherapy research Vol. 32; no. 7; pp. 1241 - 1272
Main Authors Saleem, Sumaira, Muhammad, Gulzar, Hussain, Muhammad Ajaz, Bukhari, Syed Nasir Abbas
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.07.2018
Subjects
Alkaloids
Antioxidants
Azadirachta indica
Azadirachtin
bioactives
Cancer
Carbohydrates
Complications
Dengue fever
Diabetes mellitus
Drugs
Fatty acids
Fever
Flavonoids
Fungicides
Headache
Inflammation
Leprosy
Malaria
medicinal uses
Microbicides
neem
Neuroprotection
Nimbin
Pharmaceuticals
pharmacological attributes
Pharmacology
Phytochemicals
Poultry
secondary metabolites
Skin
Steroid hormones
Steroids
Terpenes
Vector-borne diseases
azadirachtin
secondary metabolites
bioactives
pharmacological attributes
medicinal uses
neem
Azadirachta indica
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Summary:Azadirachta indica L. is a multipurpose medicinal tree of family Meliaceae. It occurs in tropical and semitropical regions of the world. Different parts of this miraculous tree are used to treat pyrexia, headache, ulcer, respiratory disorders, cancer, diabetes, leprosy, malaria, dengue, chicken pox, and dermal complications. The tree is popular for its pharmacological attributes such as hypolipidemic, antifertility, microbicidal, antidiabetic, anti‐inflammatory, hepatoprotective, antipyretic, hypoglycemic, insecticidal, nematicidal, antiulcer, antioxidant, neuroprotective, cardioprotective, and antileishmaniasis properties. A. indica is also rich in various phytochemicals for pharmaceuticals such as alkaloids, steroids, flavonoids, terpenoids, fatty acids, and carbohydrates. The fungicidal potential of the tree is due to the presence of azadirachtin and nimbin. Herein, we have compiled a comprehensive review of phytochemical profile, pharmacological attributes, and therapeutic prospective of this multipurpose tree.
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ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.6076