Higher serum ferritins are associated with higher blood pressure: A cross-sectional study
The aim of the study was to investigate the association between serum ferritin and hypertension among American adults from National Health and Nutrition Examination Survey (NHANES) 1999 to 2018. A total of 16,125 participants were included. Weighted logistic regression and subgroup analyses were per...
Saved in:
| Published in | Medicine (Baltimore) Vol. 103; no. 12; p. e37485 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Hagerstown, MD
Lippincott Williams & Wilkins
22.03.2024
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Summary: | The aim of the study was to investigate the association between serum ferritin and hypertension among American adults from National Health and Nutrition Examination Survey (NHANES) 1999 to 2018. A total of 16,125 participants were included. Weighted logistic regression and subgroup analyses were performed to explore the association. We found that serum ferritin was closely correlated to hypertension. Individuals with high serum ferritin were more likely to have higher systolic or diastolic blood pressure (SBP, DBP) than those with lower serum ferritin. Restricted cubic spline showed a significant non-linear association between serum ferritin and SBP/DBP. Higher level of serum ferritin (Q3 74.1-147 μg/L and Q4 > 147 μg/L) was found to have positive association with high SBP [Q3 (OR: 1.246, 95% CI:1.020-1.523), Q4 (OR: 1.354, 95% CI:1.096-1.674)], and hypertension [Q3 (OR: 1.283, 95% CI:1.099-1.499), Q4 (OR: 1.424, 95% CI:1.197-1.63)] in the whole population. In people aged between 20 and 60, subjects with high serum ferritin were significantly associated with a higher risk of hypertension, but in those over 60, the relationship between serum ferritin level and hypertension is negative. A non-linear association between serum ferritin and SBP, as well as DBP, was discovered. There was age difference in association between serum ferritin and hypertension in American adults, and further researches were needed to understand the mechanisms behind the difference. |
|---|---|
| Bibliography: | Received: 24 November 2023 / Received in final form: 12 February 2024 / Accepted: 13 February 2024 SL and FC contributed equally to this work. This study was supported by the National Natural Science Foundation (32070188), Research Foundation of Capital Institute of Pediatrics (ERB-2023-01), and Public service development and reform pilot project of Beijing Medical Research Institute (BMR2021-3). The funders had no role in the study design, data collection and interpretation or the decision to submit the work for publication. The protocols of NHANES were approved by NCHS Ethics Review Board, CDC, the reference number could be found through NHANES website (https://www.cdc.gov/nchs/nhanes/irba98.htm). Informed consent was obtained from all subjects involved in the study. The authors have no conflicts of interest to disclose. The datasets generated during and/or analyzed during the current study are publicly available. How to cite this article: Li S, Chen F, Li T, Cheng Y, Huang G, Hou D, Liu W, Xu T, Liu J. Higher serum ferritins are associated with higher blood pressure: A cross-sectional study. Medicine 2024;103:12(e37485). *Correspondence: Junting Liu, Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, No. 5 Dong Dan San Tiao, Dongcheng District, Beijing 100005, China (e-mail: Junting_liu@163.com). ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 0025-7974 1536-5964 1536-5964 |
| DOI: | 10.1097/MD.0000000000037485 |