Viscosities of acacia and sodium alginate after sterilization by cobalt-60

Acacia and sodium alginate powders were sterilized by cobalt-60 irradiation to a total dose of 2.5 Mrad with no increase in residual radioactivity of the gums as a result of the treatment. Viscosity measurements showed an 11% reduction in the viscosity of acacia in water and a 16% decrease in the in...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 64; no. 5; p. 802
Main Authors Hartman, A W, Nesbitt, Jr, R U, Smith, F M, Nuessle, N O
Format Journal Article
LanguageEnglish
Published United States 01.05.1975
Subjects
Acacia
Alginates
Barium
Cobalt Radioisotopes
Molecular Weight
Solutions
Sterilization
Viscosity
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Summary:Acacia and sodium alginate powders were sterilized by cobalt-60 irradiation to a total dose of 2.5 Mrad with no increase in residual radioactivity of the gums as a result of the treatment. Viscosity measurements showed an 11% reduction in the viscosity of acacia in water and a 16% decrease in the intrinsic viscosity in barium chloride solution due to the irradiation. Viscosities of sodium alginate solutions in 0.1 N sodium chloride showed a 70% decrease in intrinsic viscosity, indicating changes in the molecular structure corresponding to degradation to 30% of the original degree of polymerization. This dose of gamma-radiation from cobalt-60 is not an appropriate method of sterilization for these gums.
ISSN:0022-3549
DOI:10.1002/jps.2600640515