Molecular basis of the skin barrier structures revealed by electron microscopy

The barrier function of skin is indispensable for terrestrial animals. This function is mainly carried out by the epidermis, more specifically by its granular and cornified layers. The major structural components associated with this function are the intercellular lipid layer, desmosomes, corneodesm...

Full description

Saved in:
Bibliographic Details
Published inExperimental dermatology Vol. 27; no. 8; pp. 841 - 846
Main Authors Ishida‐Yamamoto, Akemi, Igawa, Satomi, Kishibe, Mari
Format Journal Article
LanguageEnglish
Published Denmark Wiley Subscription Services, Inc 01.08.2018
Subjects
corneodesmosome
cornified cell envelope
Desmosomes
Electron microscopy
Epidermis
Filaments
Keratin
keratohyalin granules
lamellar granules
Skin diseases
Tight junctions
Ultrastructure
corneodesmosome
keratohyalin granules
cornified cell envelope
tight junctions
lamellar granules
Online AccessGet full text

Cover

More Information
Summary:The barrier function of skin is indispensable for terrestrial animals. This function is mainly carried out by the epidermis, more specifically by its granular and cornified layers. The major structural components associated with this function are the intercellular lipid layer, desmosomes, corneodesmosomes, tight junctions, cornified cell envelope and keratin filaments. In this review, we discuss the current knowledge of their ultrastructure, their molecular basis and their relevance to skin disease.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0906-6705
1600-0625
DOI:10.1111/exd.13674