Subjective cognitive complaints and migraine characteristics: A cross‐sectional study

• Published in: Acta neurologica Scandinavica Vol. 141; no. 4; pp. 319 - 327
• Main Authors: Chu, Hsuan‐Te, Liang, Chih‐Sung, Lee, Jiunn‐Tay, Lee, Meei‐Shyuan, Sung, Yueh‐Feng, Tsai, Chia‐Lin, Tsai, Chia‐Kuang, Lin, Yu‐Kai, Ho, Tsung‐Han, Yang, Fu‐Chi
• Format: Journal Article
• Language: English
• Published: Denmark Hindawi Limited 01.04.2020
• Subjects: aura; Cognitive ability; cognitive impairment; Complaints; Cross-sectional studies; Dementia disorders; Headache; Memory; memory complaints; Migraine; Sleep; sleep quality; cognitive impairment; memory complaints; migraine; aura; sleep quality
• ISSN: 0001-6314; 1600-0404
• DOI: 10.1111/ane.13204

Objectives Subjective cognitive complaints by patients with migraine have been associated with memory impairment. However, whether the severity of memory impairment relates to migraine characteristics, such as attack frequency and aura, remains undetermined. We investigated the relationship between subjective cognitive complaints and migraine characteristics. Materials and methods This cross‐sectional study recruited 669 clinic outpatients from Taiwan. We stratified them by migraine frequency and the presence or absence of aura, and we controlled the data for confounding variables. We performed multivariable linear and logistic regressions to investigate whether different migraine frequencies are associated with subjective cognitive complaints, which were evaluated by the subjective memory complaints scale and the Ascertain Dementia 8 (AD8) questionnaire. Results Total subjective memory complaints scores tended to increase with the migraine attack frequency (P = .022) in patients with migraine with aura; similar results were obtained for AD8 scores in women with migraine with aura. Poor sleep quality was associated with a higher total subjective memory complaint (B = 0.08, 95% confidence interval [CI] = 0.03‐0.14) and AD8 (B = 0.07, 95% CI = 0.02‐0.11) scores. In addition, more severe depression was associated with higher total subjective memory complaints and AD8 scores (B = 0.05, 95% CI = 0.02‐0.09; B = 0.08, 95% CI = 0.05‐0.11, respectively). Conclusions Subjective cognitive complaints tend to increase with the frequency of migraines with aura, and this interrelation is substantially influenced by depression severity and sleep disturbances.