Yellow nail syndrome: a case report and review of treatment options

Background and Aims Yellow nail syndrome is a rare disorder involving characteristic nail changes, lymphedema and chronic respiratory symptoms. Currently there is no definitive treatment and there have been no prospective randomised controlled trials evaluating the available options. In order to str...

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Bibliographic Details
Published inThe clinical respiratory journal Vol. 11; no. 4; pp. 405 - 410
Main Authors Kurin, Michael, Wiesen, Jonathan, Mehta, Atul C.
Format Journal Article
LanguageEnglish
Published England John Wiley & Sons, Inc 01.07.2017
Subjects
Aged
Anti-Bacterial Agents - therapeutic use
Case reports
Humans
Lung Diseases - etiology
Lung Diseases - physiopathology
Lymphedema - etiology
Lymphedema - pathology
Male
Nails - pathology
Octreotide - administration & dosage
Octreotide - therapeutic use
Pleural Effusion - diagnostic imaging
Pleural Effusion - etiology
Prognosis
pulmonary disease – therapy – treatment – yellow nail syndrome
Respiratory Function Tests
Stockings, Compression - utilization
Treatment Outcome
Vitamin E - administration & dosage
Vitamin E - therapeutic use
Yellow Nail Syndrome - complications
Yellow Nail Syndrome - pathology
Yellow Nail Syndrome - therapy
pulmonary disease - therapy - treatment - yellow nail syndrome
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Summary:Background and Aims Yellow nail syndrome is a rare disorder involving characteristic nail changes, lymphedema and chronic respiratory symptoms. Currently there is no definitive treatment and there have been no prospective randomised controlled trials evaluating the available options. In order to strengthen the literature on this topic, we present the case of a 67‐year‐old man with YNS and a detailed review of current treatment options. Methods We included 40 articles for the final review according to their relevance with the subject. Results Data for use of the commonly chosen therapies for YNS remains inconclusive, with small studies and case reports showing mixed results of efficacy. Conclusion Although the date indicates that it is reasonable to recommend a trial of conservative therapy including vitamin E, antibiotics and compression stockings before pursuing more aggressive or invasive modalities, larger scale studies are required to determine the true efficacy of all treatment options.
Bibliography:Informed consent was obtained from the patient for publication of this case report and accompanying images.
Ethics
MK reviewed the literature and drafted the introduction and discussion. JWA drafted the case presentation. AM cared for the patient and critically reviewed the manuscript. All authors have provided written consent for publication.
The authors have stated explicitly that there are no conflicts of interest in connection with this article.
Authorship and contributorship
Conflict of interest
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ISSN:1752-6981
1752-699X
DOI:10.1111/crj.12354