Improved operative and survival outcomes of surgical treatment for hilar cholangiocarcinoma

• Published in: British journal of surgery Vol. 93; no. 12; pp. 1488 - 1494
• Main Authors: Liu, C. L., Fan, S. T., Lo, C. M., Tso, W. K., Lam, C. M., Wong, J.
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.2006; Wiley
• Subjects: Aged; Bile Duct Neoplasms - mortality; Bile Duct Neoplasms - surgery; Bile Ducts, Intrahepatic - surgery; Biological and medical sciences; Blood Loss, Surgical - prevention & control; Cholangiocarcinoma - mortality; Cholangiocarcinoma - surgery; Disease-Free Survival; Embolization, Therapeutic - methods; Female; General aspects; Hepatectomy - methods; Hepatectomy - mortality; Humans; Lymph Node Excision - methods; Male; Medical sciences; Middle Aged; Multivariate Analysis; Portal Vein - surgery; Prospective Studies; Retrospective Studies; Survival Analysis; Treatment Outcome; Medicine; Prognosis; Treatment; Hilar cholangiocarcinoma; Surgery; Evolution; Survival
• ISSN: 0007-1323; 1365-2168
• DOI: 10.1002/bjs.5482

Background: The aim of the present study was to assess whether an aggressive surgical approach in the management of patients with hilar cholangiocarcinoma was associated with improved operative and survival outcomes. Methods: Eighty‐two patients with hilar cholangiocarcinoma treated between 1989 and 1998 (period 1), and 60 patients treated between 1999 and 2004 (period 2), were evaluated. Modifications to management in period 2 primarily included percutaneous biliary drainage instead of endoscopic drainage for relief of obstructive jaundice, preoperative right portal vein embolization before right‐sided hepatectomy, routine total caudate lobectomy and radical lymphadenectomy during surgical resection of the tumour. Results: The surgical resection rate was significantly higher in period 2 than in period 1 (45 versus 16 per cent; P < 0·001). All patients in period 2 underwent major hepatectomy with concomitant caudate lobectomy. The operative morbidity and hospital mortality rates decreased significantly in period 2 compared with period 1, with significantly better survival outcomes. In multivariate analysis, resection of the tumour in period 2 and operative blood loss of 1·5 litres or less were the significant independent factors associated with improved survival. Conclusion: An aggressive surgical approach was associated with improved operative and survival outcomes for patients with hilar cholangiocarcinoma. Copyright © 2006 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd. By aggressive and meticulous surgery