Body mass index and all‐cause mortality among older adults
Objective To examine the association between baseline body mass index (BMI, kg/m2) and all‐cause mortality in a well‐characterized cohort of older persons. Methods The association between BMI (both as a categorical and continuous variable) and all‐cause mortality was investigated using 4,565 Geising...
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Published in | Obesity (Silver Spring, Md.) Vol. 24; no. 10; pp. 2232 - 2239 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.10.2016
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Subjects | |
Online Access | Get full text |
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Summary: | Objective
To examine the association between baseline body mass index (BMI, kg/m2) and all‐cause mortality in a well‐characterized cohort of older persons.
Methods
The association between BMI (both as a categorical and continuous variable) and all‐cause mortality was investigated using 4,565 Geisinger Rural Aging Study participants with baseline age 74.0 ± 4.7 years (mean ± SD) and BMI 29.5 ± 5.3 kg/m2 over a mean of 10.9 ± 3.8 years of follow‐up.
Results
The relationship between BMI (as a continuous variable) and all‐cause mortality was found to be U‐shaped (P nonlinearity <0.001). Controlling for age, sex, smoking, alcohol, laboratory values, medications, and comorbidity status, underweight (BMI <18.5 kg/m2) individuals had significantly greater adjusted risk of all‐cause mortality than persons of BMI 18.5 to 24.9 kg/m2 (reference range). Participants with overweight (BMI 25.0–29.9 kg/m2) and class I obesity (BMI 30.0–34.9 kg/m2) had significantly lower adjusted‐risk of all‐cause mortality. Those with classes II/III obesity (BMI ≥ 35.0 kg/m2) did not have significantly greater adjusted‐risk of all‐cause mortality. Findings were consistent using propensity score weights and among never‐smokers with 2‐ and 5‐year lag analysis and among those with no identified chronic disease.
Conclusions
A U‐shaped association was observed between BMI and all‐cause mortality with lower risk among older persons with overweight and class I obesity in comparison with those with BMI 18.5 to 24.9 kg/m2. |
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Bibliography: | All authors declared no conflict of interests. Disclosure Funding agencies This work was supported by the United States Department of Agriculture, Agricultural Research Service agreement 8050‐51530‐012‐01A. Author contributions Conception and design: all authors. Analysis and interpretation of the data: FWC, XG, and GLJ. Drafting of the article: FWC, XG, and GLJ. Critical revision of the article for important intellectual content: all authors. Final approval of the article: all authors. Provision of study materials or patients: all authors. Statistical expertise: FWC, XG, CW, and GLJ. Obtaining of funding: GLJ. Administrative, technical, or logistic support: all authors. Collection and assembly of data: all authors. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1930-7381 1930-739X |
DOI: | 10.1002/oby.21612 |