Studies on Aldose Reductase Inhibitors from Natural Products. II. : Active Components of a Paraguayan Crude Drug "Para-parai mi, " Phyllanthus niruri
Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mi, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the hig...
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| Published in | Chem. Pharm. Bull Vol. 37; no. 9; pp. 2531 - 2532 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Tokyo
The Pharmaceutical Society of Japan
1989
公益社団法人日本薬学会 Maruzen |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0009-2363 1347-5223 |
| DOI | 10.1248/cpb.37.2531 |
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| Abstract | Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mi, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR. |
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| AbstractList | Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mí, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR.Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mí, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR. Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mi, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR. Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mí, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR. |
| Author | HORIE, Syunji TERASHIMA, Satoshi MORITA, Naokata HAYASHI, Toshimitsu SHIMIZU, Mineo UENO, Hajime YOSHIZAKI, Masao ARISAWA, Munehisa SUZUKI, Shoichi |
| Author_FL | UENO Hajime ARISAWA Munehisa SUZUKI Shoichi HAYASHI Toshimitsu SHIMIZU M YOSHIZAKI Masao HORIE Syunji TERASHIMA Satoshi MORITA Naokata |
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| Keywords | South America Rat Extract Identification Paraguay Medicinal plant Eye Enzymatic activity Folk medicine Dicotyledones America Angiospermae Euphorbiaceae Pharmacognosy Rodentia Enzyme inhibitor In vitro Vertebrata Mammalia Aldose reductase Animal Isolation Active ingredient Spermatophyta Lens |
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| References | 3) H. Ueno, S. Horie, Y. Nishi, H. Shogawa, M. Kawasaki, S. Suzuki, T. Hayashi, M. Arisawa, M. Shimizu, M. Yoshizaki, N. Morita, L.H. Berganza, E. Ferro and I. Basualdo, J. Nat. Prod., 51, 357 (1988). 5) O.T. Schmidt and K. Bernauer, Justus Liebigs Ann. Chem., 588, 211 (1954). 11) M. Shimizu, T. Ito, S. Terashima, T. Hayashi, M. Arisawa and N. Morita, Phytochemistry, 23, 1885 (1984). 6) T. Okuda, T. Yoshida and K. Mori, Yakugaku Zasshi, 95, 1462 (1975). 4) T. Okuda, T. Yoshida and K. Mori, Phytochemistry, 14, 1877 (1975). 8) T. Okuda, K. Mori and M. Ishino, Yakugaku Zasshi, 99, 505 (1979). 10) P.F. Kador and N.E. Sharpless, Biophys, Chem., 8, 81 (1978). 1) M. Shimizu, S. Horie, M. Arisawa, T. Hayashi, S. Suzuki, M. Yoshizaki, M. Kawasaki, S. Terashima, H. Tsuji, S. Wada, H. Ueno, N. Morita, L.H. Berganza, E. Ferro and I. Basualdo, Chem. Pharm. Bull., 35, 1234 (1987). 9) T. Okuda, K. Mori and T. Hatano, Phytochemistry, 19, 547 (1980). 7) T. Okuda, T. Yoshida and H. Nayeshiro, Chem. Pharm. Bull., 25, 1862 (1977). |
| References_xml | – reference: 9) T. Okuda, K. Mori and T. Hatano, Phytochemistry, 19, 547 (1980). – reference: 3) H. Ueno, S. Horie, Y. Nishi, H. Shogawa, M. Kawasaki, S. Suzuki, T. Hayashi, M. Arisawa, M. Shimizu, M. Yoshizaki, N. Morita, L.H. Berganza, E. Ferro and I. Basualdo, J. Nat. Prod., 51, 357 (1988). – reference: 8) T. Okuda, K. Mori and M. Ishino, Yakugaku Zasshi, 99, 505 (1979). – reference: 4) T. Okuda, T. Yoshida and K. Mori, Phytochemistry, 14, 1877 (1975). – reference: 6) T. Okuda, T. Yoshida and K. Mori, Yakugaku Zasshi, 95, 1462 (1975). – reference: 7) T. Okuda, T. Yoshida and H. Nayeshiro, Chem. Pharm. Bull., 25, 1862 (1977). – reference: 11) M. Shimizu, T. Ito, S. Terashima, T. Hayashi, M. Arisawa and N. Morita, Phytochemistry, 23, 1885 (1984). – reference: 5) O.T. Schmidt and K. Bernauer, Justus Liebigs Ann. Chem., 588, 211 (1954). – reference: 10) P.F. Kador and N.E. Sharpless, Biophys, Chem., 8, 81 (1978). – reference: 1) M. Shimizu, S. Horie, M. Arisawa, T. Hayashi, S. Suzuki, M. Yoshizaki, M. Kawasaki, S. Terashima, H. Tsuji, S. Wada, H. Ueno, N. Morita, L.H. Berganza, E. Ferro and I. Basualdo, Chem. Pharm. Bull., 35, 1234 (1987). |
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| Snippet | Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mi, Phyllanthus niruri, has led to the isolation of... Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mí, Phyllanthus niruri, has led to the isolation of... |
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| SubjectTerms | Aldehyde Reductase - antagonists & inhibitors aldose reductase inhibitor Analysis Animals Biological and medical sciences brevifolin carboxylic acid ellagic acid ethyl brevifolin carboxylate Euphorbiaceae General pharmacology In Vitro Techniques Medical sciences Paraguay Pharmacology. Drug treatments Phyllanthus niruri Plants, Medicinal - analysis Rats Sugar Alcohol Dehydrogenases - antagonists & inhibitors |
| Title | Studies on Aldose Reductase Inhibitors from Natural Products. II. : Active Components of a Paraguayan Crude Drug "Para-parai mi, " Phyllanthus niruri |
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