Studies on Aldose Reductase Inhibitors from Natural Products. II. : Active Components of a Paraguayan Crude Drug "Para-parai mi, " Phyllanthus niruri

• Published in: Chem. Pharm. Bull Vol. 37; no. 9; pp. 2531 - 2532
• Main Authors: HAYASHI, Toshimitsu, HORIE, Syunji, TERASHIMA, Satoshi, UENO, Hajime, MORITA, Naokata, YOSHIZAKI, Masao, ARISAWA, Munehisa, SUZUKI, Shoichi, SHIMIZU, Mineo
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1989; 公益社団法人日本薬学会; Maruzen
• Subjects: Aldehyde Reductase - antagonists & inhibitors; aldose reductase inhibitor; Analysis; Animals; Biological and medical sciences; brevifolin carboxylic acid; ellagic acid; ethyl brevifolin carboxylate; Euphorbiaceae; General pharmacology; In Vitro Techniques; Medical sciences; Paraguay; Pharmacology. Drug treatments; Phyllanthus niruri; Plants, Medicinal - analysis; Rats; Sugar Alcohol Dehydrogenases - antagonists & inhibitors; Paraguay; South America; Rat; Extract; Identification; Paraguay; Medicinal plant; Eye; Enzymatic activity; Folk medicine; Dicotyledones; America; Angiospermae; Euphorbiaceae; Pharmacognosy; Rodentia; Enzyme inhibitor; In vitro; Vertebrata; Mammalia; Aldose reductase; Animal; Isolation; Active ingredient; Spermatophyta; Lens
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.37.2531

Aldose reductase (AR) inhibitory activity-directed fractionation of the 70% ethanolic extract of Para-parai mi, Phyllanthus niruri, has led to the isolation of three active components, ellagic acid (1), brevifolin carboxylic acid (4) and ethyl brevifolin carboxylate (5). Among them, 1 showed the highest inhibitory activity, being about 6 times more potent than quercitrin, which is a known natural inhibitor of AR.