Prenatal paraben exposure and atopic dermatitis‐related outcomes among children
Background Parabens, widely used as preservatives in cosmetics, foods, and other consumer products, are suspected of contributing to allergy susceptibility. The detection of parabens in the placenta or amniotic fluid raised concerns about potential health consequences for the child. Recently, an inc...
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Published in | Allergy (Copenhagen) Vol. 76; no. 10; pp. 3122 - 3132 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Denmark
Blackwell Publishing Ltd
01.10.2021
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Subjects | |
Online Access | Get full text |
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Summary: | Background
Parabens, widely used as preservatives in cosmetics, foods, and other consumer products, are suspected of contributing to allergy susceptibility. The detection of parabens in the placenta or amniotic fluid raised concerns about potential health consequences for the child. Recently, an increased asthma risk following prenatal exposure has been reported. Here, we investigated whether prenatal paraben exposure can influence the risk for atopic dermatitis (AD).
Methods
261 mother‐child pairs of the German mother‐child study LINA were included in this analysis. Eight paraben species were quantified in maternal urine obtained at gestational week 34. According to the parental report of physician‐diagnosed AD from age 1 to 8 years, disease onset, and persistence, childhood AD was classified into four different phenotypes.
Results
4.6% (n = 12) and 12.3% (n = 32) of the children were classified as having very early‐onset AD (until age two) either with or without remission, 11.9% (n = 31) as early‐onset (after age two), and 3.1% (n = 8) as childhood‐onset AD (after age six). Exposure to ethylparaben and n‐butylparaben was associated with an increased risk to develop very early‐onset AD without remission (EtP: adj.OR/95% CI:1.44/1.04–2.00,nBuP:adj.OR/95% CI:1.95/1.22–3.12). The effects of both parabens were predominant in children without a history of maternal AD and independent of children's sex.
Conclusion
Prenatal EtP or nBuP exposure may increase children's susceptibility for persistent AD with disease onset at very early age. This association was particularly pronounced in children without a history of maternal AD, indicating that children without a genetic predisposition are more susceptible to paraben exposure.
Different paraben species, widely used as preservatives in consumer products, were detected in the urine of pregnant women. Prenatal ethylparaben and n‐butylparaben exposure are associated with an increased risk for very early‐onset atopic dermatitis without remission independent of the child's sex. This risk increase predominantly affects children without a history of maternal atopic dermatitis. Abbreviation: AD, atopic dermatitis |
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Bibliography: | Loreen Thürmann, Gunda Herberth, Bettina Seiwert, Saskia Trump, Thorsten Reemtsma, and Irina Lehmann equal contribution. |
ISSN: | 0105-4538 1398-9995 |
DOI: | 10.1111/all.14890 |