Platelet-collagen interactions: membrane receptors and intracellular signalling pathways

• Published in: European journal of clinical investigation Vol. 29; no. 12; pp. 1066 - 1076
• Main Authors: ALBERIO, L, DALE, G. L
• Format: Journal Article
• Language: English
• Published: Oxford BSL Blackwell Science Ltd 01.12.1999; Blackwell; Blackwell Publishing Ltd
• Subjects: Biological and medical sciences; Collagen; Fundamental and applied biological sciences. Psychology; glycoprotein VI; integrin α2β1; platelet; receptors; signal transduction; Vertebrates: blood, hematopoietic organs, reticuloendothelial system; Human; Blood coagulation; Signal transduction; Membrane receptor; Platelet; Integrin; Hemostasis; Collagen; Glycoprotein; Cell substratum interaction; Thrombosis
• ISSN: 0014-2972; 1365-2362
• DOI: 10.1046/j.1365-2362.1999.00570.x

Platelet adhesion to and activation by exposed subendothelial collagen plays a critical role in normal haemostasis and pathological thrombosis. Recent advances in elucidating the mechanisms underlying platelet–collagen interaction support a ‘two‐site, two‐step’ model. Direct platelet binding to integrin α2β1 mainly sustains adhesion and allows recognition of glycoprotein VI. The latter interaction is responsible for characteristic intracellular signalling events leading to p72Syk and PLCγ2 activation. The present review describes the known collagen receptors on platelets and discusses the current understanding of signal transduction promoted by collagen.