Emerging concepts and challenges in implementing the exposome paradigm in allergic diseases and asthma: a Practall document

Exposome research can improve the understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the life span. The exposomic approach provides a risk profile instead of single predictors and thus is particularly applicable to allergic disea...

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Published inAllergy (Copenhagen) Vol. 74; no. 3; pp. 449 - 463
Main Authors Agache, Ioana, Miller, Rachel, Gern, James E., Hellings, Peter W., Jutel, Marek, Muraro, Antonella, Phipatanakul, Wanda, Quirce, Santiago, Peden, David
Format Journal Article
LanguageEnglish
Published Denmark Blackwell Publishing Ltd 01.03.2019
Subjects
Allergic diseases
Allergies
Asthma
Asthma - diagnosis
Asthma - epidemiology
Asthma - etiology
Asthma - metabolism
Big Data
Biomarkers
Disease Susceptibility
environment
Europe
Exposome
Exposure
Genetic Predisposition to Disease
Genomics - methods
Humans
Hypersensitivity
Hypersensitivity - diagnosis
Hypersensitivity - epidemiology
Hypersensitivity - etiology
Hypersensitivity - metabolism
Immunology
Life span
PRACTALL
Precision Medicine
Proteomics - methods
Risk Assessment
Risk Factors
United States
United States
Europe
environment
asthma
exposome
biomarkers
PRACTALL
allergic diseases
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Summary:Exposome research can improve the understanding of the mechanistic connections between exposures and health to help mitigate adverse health outcomes across the life span. The exposomic approach provides a risk profile instead of single predictors and thus is particularly applicable to allergic diseases and asthma. Under the PRACTALL collaboration between the European Academy of Allergy and Clinical Immunology (EAACI) and the American Academy of Allergy, Asthma, and Immunology (AAAAI), we evaluated the current concepts and the unmet needs on the role of the exposome in allergic diseases and asthma.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0105-4538
1398-9995
DOI:10.1111/all.13690