Circulating tumor DNA as a biomarker and liquid biopsy in head and neck squamous cell carcinoma

The use of circulating biochemical molecular markers in head and neck cancer holds the promise of improved diagnostics, treatment planning, and posttreatment surveillance. In this review, we provide an introduction for the head and neck surgeon of the basic science, current evidence, and future appl...

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Published inHead & neck Vol. 40; no. 7; pp. 1598 - 1604
Main Authors Payne, Karl, Spruce, Rachel, Beggs, Andrew, Sharma, Neil, Kong, Anthony, Martin, Timothy, Parmar, Satyesh, Praveen, Prav, Nankivell, Paul, Mehanna, Hisham
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.07.2018
Subjects
biomarker
Biomarkers
Biomarkers, Tumor - blood
Biopsy
Carcinoma, Squamous Cell - blood
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - genetics
circulating tumor DNA (ctDNA)
Deoxyribonucleic acid
DNA
DNA, Neoplasm - blood
Head & neck cancer
head and neck cancer
Head and Neck Neoplasms - blood
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - genetics
Humans
Liquid Biopsy
Neck
Squamous cell carcinoma
head and neck cancer
biomarker
circulating tumor DNA (ctDNA)
liquid biopsy
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Summary:The use of circulating biochemical molecular markers in head and neck cancer holds the promise of improved diagnostics, treatment planning, and posttreatment surveillance. In this review, we provide an introduction for the head and neck surgeon of the basic science, current evidence, and future applications of circulating tumor DNA (ctDNA) as a biomarker and liquid biopsy to detect tumor genetic heterogeneity in patients with head and neck squamous cell carcinoma (HNSCC).
Bibliography:Funding information
Paul Nankivell and Hisham Mehanna contributed equally to this study as senior authors.
This article was published online on 15 March 2018. An error was subsequently identified. This notice is included in the online and print versions to indicate that both have been corrected 20 April 2018.
Section Editor: Patrick Ha, MD
Grant sponsor: Cancer Research UK (to Hisham Mehanna), Grant sponsor: The Wellcome Trust, Grant Number: 102732/Z/13/Z, Grant sponsor: Cancer Research UK, Grant Number: C31641/A23923, Grant sponsor: The Medical Research Council, Grant Number: MR/M016587/1 (to Andrew Beggs)
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1043-3074
1097-0347
DOI:10.1002/hed.25140