Long-term air pollution exposure and decreased kidney function: A longitudinal cohort study in Bangkok Metropolitan Region, Thailand from 2002 to 2012

• Published in: Chemosphere (Oxford) Vol. 287; no. Pt 1; p. 132117
• Main Authors: Paoin, Kanawat, Ueda, Kayo, Vathesatogkit, Prin, Ingviya, Thammasin, Buya, Suhaimee, Dejchanchaiwong, Racha, Phosri, Arthit, Seposo, Xerxes Tesoro, Kitiyakara, Chagriya, Thongmung, Nisakron, Honda, Akiko, Takano, Hirohisa, Sritara, Piyamitr, Tekasakul, Perapong
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.01.2022
• Subjects: aerodynamics; air; Air pollution; carbon monoxide; Cardiovascular risk factor; chronic exposure; cohort studies; confidence interval; creatinine; electricity; Estimated glomerular filtration rate; glomerular filtration rate; Kidney dysfunction; kidneys; kriging; Long-term exposure; longitudinal studies; nitrogen dioxide; ozone; particulates; regression analysis; relative humidity; risk factors; sulfur dioxide; temperature; Thailand; Thailand; Long-term exposure; Air pollution; Kidney dysfunction; Cardiovascular risk factor; Estimated glomerular filtration rate
• ISSN: 0045-6535; 1879-1298; 1879-1298
• DOI: 10.1016/j.chemosphere.2021.132117

Kidney dysfunction is considered a cardiovascular risk factor. However, few longitudinal studies have examined the effects of air pollution on kidney function. We evaluated associations between long-term air pollution exposure and estimated glomerular filtration rate (eGFR) using data from a cohort of the Electricity Generating Authority of Thailand (EGAT) study in Bangkok Metropolitan Region, Thailand. This longitudinal study included 1839 subjects (aged 52–71 years in 2002) from the EGAT1 cohort study during 2002–2012. eGFR, based on creatinine, was measured in 2002, 2007, and 2012. Annual mean concentrations of air pollutants (i.e., particulate matter with an aerodynamic diameter ≤10 μm (PM10), ozone (O3), nitrogen dioxide (NO2), sulfur dioxide (SO2), and carbon monoxide (CO)) prior to a measurement of creatinine were assessed with the ordinary kriging method. Mixed-effect linear regression models were used to assess associations between air pollutants and eGFR, while controlling for potential covariates. eGFR values are expressed as percent change per interquartile range (IQR) increments of each pollutant. Lower eGFR was associated with higher concentrations of PM10 (−1.99%, 95% confidence interval (CI): −3.33, −0.63), SO2 (−4.89%, 95%CI: −6.69, −3.07), and CO (−0.97%, 95%CI: −1.96, 0.03). However, after adjusting for temperature, relative humidity, PM10, and SO2, no significant association was observed between CO and eGFR. Our findings support the hypothesis that long-term exposure to high concentrations of PM10 and SO2 is associated with the progression of kidney dysfunction in subjects of the EGAT cohort study. •Estimated glomerular filtration rate (eGFR) is used for kidney disease staging.•Long-term exposure to PM10 and SO2 was associated with lower eGFR.•These findings suggest that air pollution affects kidney function.