Application of electron paramagnetic resonance spectroscopy for validation of the novel (AN+DN) solvent polarity scale

Based on solvation studies of polymers, the sum (1:1) of the electron acceptor (AN) and electron donor (DN) values of solvents has been proposed as an alternative polarity scale. To test this, the electron paramagnetic resonance isotropic hyperfine splitting constant, a parameter known to be depende...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 9; no. 7; pp. 1321 - 1332
Main Authors Malavolta, Luciana, Poletti, Erick F, Silva, Elias H, Schreier, Shirley, Nakaie, Clovis R
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.07.2008
Subjects
Alzheimer's disease
EPR
isotropic hyperfine splitting constant
Peptides
polarity
Regression analysis
solvent
Solvents
spin label
Brazil
solvent
EPR
isotropic hyperfine splitting constant
spin label
polarity
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Summary:Based on solvation studies of polymers, the sum (1:1) of the electron acceptor (AN) and electron donor (DN) values of solvents has been proposed as an alternative polarity scale. To test this, the electron paramagnetic resonance isotropic hyperfine splitting constant, a parameter known to be dependent on the polarity/proticity of the medium, was correlated with the (AN+DN) term using three paramagnetic probes. The linear regression coefficient calculated for 15 different solvents was approximately 0.9, quite similar to those of other well-known polarity parameters, attesting to the validity of the (AN+DN) term as a novel "two-parameter" solvent polarity scale.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms9071321