Chronobiological aspects of nutrition, metabolic syndrome and obesity

The present review starts from the classical physiological and nutritional studies related with food intake control, digestion, transport and absorption of nutrients. It continues with studies related with the metabolism of adipose tissue, and finish with modern experiments in genetics and molecular...

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Bibliographic Details
Published inAdvanced drug delivery reviews Vol. 62; no. 9; pp. 967 - 978
Main Authors Garaulet, Marta, Madrid, Juan Antonio
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 31.07.2010
Subjects
Adipose tissue
Adipose Tissue - metabolism
Animals
Bmal1
Chronodisruption
Circadian
Circadian Clocks - physiology
Clock
Clock genes
Cry
Digestion - physiology
Eating - physiology
Humans
Melatonin
Metabolic Syndrome - physiopathology
Molecular Biology - methods
Obesity - physiopathology
Per1
Rhythmicity
Per1
Melatonin
Rhythmicity
Clock genes
Cry
Circadian
Clock
Bmal1
Chronodisruption
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Summary:The present review starts from the classical physiological and nutritional studies related with food intake control, digestion, transport and absorption of nutrients. It continues with studies related with the metabolism of adipose tissue, and finish with modern experiments in genetics and molecular biology — all from a fresh, chronobiological point of view. Obesity will be explained as a fault in the circadian system, as pathology associated with “chronodisruption”. The main gaps in chronobiological research related to obesity will be also identified and chronobiological-based therapies will be proposed in order to allow the resetting of the circadian rhythm among obese subjects.
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ISSN:0169-409X
1872-8294
1872-8294
DOI:10.1016/j.addr.2010.05.005