Advanced Age Is a Risk Factor for Recurrence After Resection in Stage II Colorectal Cancer

• Published in: In vivo (Athens) Vol. 34; no. 1; pp. 339 - 346
• Main Authors: Mima, Kosuke, Kurashige, Junji, Miyanari, Nobutomo, Morito, Atsushi, Yumoto, Shinsei, Matsumoto, Takashi, Kosumi, Keisuke, Inoue, Mitsuhiro, Mizumoto, Takao, Kubota, Tatsuo, Baba, Hideo
• Format: Journal Article
• Language: English
• Published: Greece International Institute of Anticancer Research 01.01.2020
• Subjects: mortality; geriatrics; Carcinoma; gerontology; morbidity
• ISSN: 0258-851X; 1791-7549
• DOI: 10.21873/invivo.11779

The number of older patients with colorectal cancer (CRC) is increasing. Stage II CRC is a heterogeneous group of cancers with different prognoses. We aimed to examine older patients in relation to clinical outcome following curative resection in stage II CRC. We analyzed data for 329 consecutive patients with stage II CRC following curative resection. Recurrence-free survival (RFS) and overall survival (OS) were compared between older patients ≥75 years of age and those <75 years. Cox proportional hazards model was used to compute hazard ratios (HRs) controlling for potential confounders. In the multivariable analyses, patients ≥75 years were independently associated with shorter RFS (multivariable HR=2.56, 95% confidence interval (CI)=1.55-4.31, p<0.001) and OS (multivariable HR=4.36, 95%CI=2.08-9.97, p<0.001) in stage II CRC. Older patients were independently associated with shorter RFS and OS following curative resection in stage II CRC.