Self-sterilizing ormosils surfaces based on photo-synzthesized silver nanoparticles

• Published in: Colloids and surfaces, B, Biointerfaces Vol. 164; pp. 144 - 154
• Main Authors: Gonçalves, Lidiane Patrícia, Miñán, Alejandro, Benítez, Guillermo, de Mele, Mónica Fernández Lorenzo, Vela, María Elena, Schilardi, Patricia L., Ferreira-Neto, Elias Paiva, Noveletto, Júlia Cristina, Correr, Wagner Rafael, Rodrigues-Filho, Ubirajara Pereira
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.04.2018
• Subjects: Ag nanoparticles; Antibacterial activity; Ormosil; Pseudomonas aeruginosa; Staphylococcus aureus; CS; NPs; POrs-CS; POrs-CS-Ag; POrs; AgNPs; Ormosil; Antibacterial activity; Pseudomonas aeruginosa; Ag nanoparticles; Staphylococcus aureus; POrs-Ag
• ISSN: 0927-7765; 1873-4367
• DOI: 10.1016/j.colsurfb.2017.12.016

[Display omitted] •A straightforward and robust antibacterial coating was developed.•The coating consists in phosphotungstate ormosil doped with core-shell (SiO2@TiO2).•Silver nanoparticles were included in the coating by photoassisted synthesis.•The coating is able to eradicate Gram(+) and Gram(−) bacteria.•The antimicrobial activity remains high until three reutilization cycles. Medical device-related infections represent a major healthcare complication, resulting in potential risks for the patient. Antimicrobial materials comprise an attractive strategy against bacterial colonization and biofilm proliferation. However, in most cases these materials are only bacteriostatic or bactericidal, and consequently they must be used in combination with other antimicrobials in order to reach the eradication condition (no viable microorganisms). In this study, a straightforward and robust antibacterial coating based on Phosphotungstate Ormosil doped with core-shell (SiO2@TiO2) was developed using sol-gel process, chemical tempering, and Ag nanoparticle photoassisted synthesis (POrs-CS-Ag). The coating was characterized by X-ray Fluorescence Spectroscopy (XRF), Field Emission Scanning Electron Microscopy (FE-SEM), Atomic Force Microscopy (AFM) and X-ray Photoelectron Microscopy (XPS). The silver free coating displays low antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, in opposition to the silver loaded ones, which are able to completely eradicate these strains. Moreover, the antimicrobial activity of these substrates remains high until three reutilization cycles, which make them a promising strategy to develop self-sterilizing materials, such as POrs-CS-Ag-impregnated fabric, POrs-CS-Ag coated indwelling metals and polymers, among other materials.