Immunogenicity of Haemophilus influenzae Type b Conjugate Vaccine in Allogeneic Bone Marrow Recipients

• Published in: The Journal of infectious diseases Vol. 166; no. 5; pp. 1021 - 1028
• Main Authors: Barra, Anne, Cordonnier, Catherine, Preziosi, Marie-Pierre, Intrator, Liliane, Hessel, Luc, Fritzell, Bernard, Preud'homme, Jean-Louis
• Format: Journal Article
• Language: English
• Published: United States The University of Chicago Press 01.11.1992; University of Chicago Press
• Subjects: Adult; Antibodies; Antibody formation; Bacterial Vaccines - immunology; Bacterial Vaccines - therapeutic use; Bone marrow; Bone Marrow Transplantation - immunology; Conjugate vaccines; Female; Follow-Up Studies; Haemophilus Infections - immunology; Haemophilus Infections - prevention & control; Haemophilus influenzae; Haemophilus influenzae - immunology; Haemophilus influenzae type b; Humans; Immunization; Immunoglobulin G - blood; Infections; Major Articles; Male; Polysaccharides; Polysaccharides, Bacterial - immunology; Tetanus Toxoid - immunology; Tetanus Toxoid - therapeutic use; Tissue grafting; Transplantation, Homologous; Vaccination; Vaccines, Synthetic - immunology; Vaccines, Synthetic - therapeutic use
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/166.5.1021

A randomized study was conducted in 40 allogeneic marrow recipients to compare the immunogenicity of two Haemophilus injluenzae type b (Hib) vaccines (either the Hib capsular polysaccharide [Hib-CPS] or tetanus toxoid-conjugated Hib-CPS [Hib-CPS-T]). A second injection consisted of Hib-CPS-T. Before immunization, 3 patients had serum antibody levels > 1 µg/mL. After the first injection, the response was better after Hib-CPS-T than after Hib-CPS but lower than in normal subjects; a number of patients lacked any IgG antibody response, especially after Hib-CPS. Of patients who received two injections of Hib-CPS-T, 85% achieved an antibody concentration ⩾1 µg/mL. Hib-CPS-T induced a response in IgG2-deficient patients whereas Hib-CPS alone did not. IgG antibodies predominantly belonged to the IgG1 subclass. The antibody response was better in patients immunized late after graft. This study shows that Hib-CPS-T is more immunogenic than Hib-CPS in marrow recipients.