Immunogenicity of Haemophilus influenzae Type b Conjugate Vaccine in Allogeneic Bone Marrow Recipients
A randomized study was conducted in 40 allogeneic marrow recipients to compare the immunogenicity of two Haemophilus injluenzae type b (Hib) vaccines (either the Hib capsular polysaccharide [Hib-CPS] or tetanus toxoid-conjugated Hib-CPS [Hib-CPS-T]). A second injection consisted of Hib-CPS-T. Before...
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Published in | The Journal of infectious diseases Vol. 166; no. 5; pp. 1021 - 1028 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
The University of Chicago Press
01.11.1992
University of Chicago Press |
Subjects | |
Online Access | Get full text |
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Summary: | A randomized study was conducted in 40 allogeneic marrow recipients to compare the immunogenicity of two Haemophilus injluenzae type b (Hib) vaccines (either the Hib capsular polysaccharide [Hib-CPS] or tetanus toxoid-conjugated Hib-CPS [Hib-CPS-T]). A second injection consisted of Hib-CPS-T. Before immunization, 3 patients had serum antibody levels > 1 µg/mL. After the first injection, the response was better after Hib-CPS-T than after Hib-CPS but lower than in normal subjects; a number of patients lacked any IgG antibody response, especially after Hib-CPS. Of patients who received two injections of Hib-CPS-T, 85% achieved an antibody concentration ⩾1 µg/mL. Hib-CPS-T induced a response in IgG2-deficient patients whereas Hib-CPS alone did not. IgG antibodies predominantly belonged to the IgG1 subclass. The antibody response was better in patients immunized late after graft. This study shows that Hib-CPS-T is more immunogenic than Hib-CPS in marrow recipients. |
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Bibliography: | Present affiliation: Connaught Laboratories, Swiftwater, Pennsylvania. Reprints or correspondence: Dr. C. Cordonnier, Service d'Hématologie Clinique, Hôpital Henri Mondor, 51, Avenue du Maréchal Delattre de Tassigny, 94000-Creteil, France. ark:/67375/HXZ-FLWT97KR-Q istex:DF5C35554F36B59FA80DB9C11F4C86DE1EE55B04 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-News-3 |
ISSN: | 0022-1899 1537-6613 |
DOI: | 10.1093/infdis/166.5.1021 |