Thiol-ene clickable hyaluronans: From macro-to nanogels

• Published in: Journal of colloid and interface science Vol. 419; no. 419; pp. 52 - 55
• Main Authors: Hachet, Emilie, Sereni, Nicolas, Pignot-Paintrand, Isabelle, Ravaine, Valérie, Szarpak-Jankowska, Anna, Auzély-Velty, Rachel
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.04.2014; Elsevier
• Subjects: Chemical Sciences; Chemistry; Colloidal gels. Colloidal sols; Colloidal state and disperse state; Crosslinking; Density; Drug Delivery Systems; Exact sciences and technology; General and physical chemistry; Hyaluronic acid; Hyaluronic Acid - chemistry; Hydrogels; Hydroxyapatite; Liposomes; Material chemistry; Membranes; Nanogels; Nanoparticles - chemistry; Nanostructure; Precursors; Stimuli-responsive hydrogels; Swelling; Thiol-ene coupling; Nanogels; Stimuli-responsive hydrogels; Thiol-ene coupling; Liposomes; Hyaluronic acid; Colloidal gel; Thiol; Nanogel; Liposome; Hydrogel
• ISSN: 0021-9797; 1095-7103
• DOI: 10.1016/j.jcis.2013.12.044

[Display omitted] •The fabrication of hyaluronan-based nanogels in liposome nanoreactors is presented.•Pentenoate-modified hyaluronan is crosslinked by poly(ethylene glycol)-bis(thiol).•Crosslinking density is controlled by the degree of substitution of hyaluronan. The fabrication of hyaluronic acid (HA) nanogels using a thiol-ene reaction has been demonstrated. HA was modified with pentenoate groups and then cross-linked with poly(ethylene glycol)-bis(thiol) by exposure to UV light. The cross-linking density and thereby the rigidity of the obtained gels were precisely controlled by the degree of substitution of pentenoate-modified HA. Their swelling properties also depended on cross-linking density. To produce hydrogels at the nanoscale, hyaluronic acid precursors were solely confined inside liposomes before cross-linking and purified after cross-linking. The size of the resulting nanogels followed their swelling properties and was also affected by their cross-linking density. Such bionanogels with tunable mechanical and swelling properties have potential in drug delivery.