Lumpy Skin Disease (LSD) in Yak ( Bos grunniens ): An Evidence of Species Spillover from Cattle in India

• Published in: Microorganisms (Basel) Vol. 11; no. 12; p. 2823
• Main Authors: Manjunatha Reddy, Gundallahalli Bayyappa, Pabbineedi, Sai Mounica, Nagaraj, Sudeep, Bijalwan, Shraddha, Tadakod, Sunil, Bhutia, Zeruiah, Palmu, Diki, Rai, Seema, Bhutia, Pempa Doma, Bhutia, Pem Tshering, Shenga, Emila, Gulati, Baldev Raj
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.11.2023
• Subjects: Animal husbandry; Antibodies; Cattle; Control programs; Disease control; Epidemics; G protein-coupled receptors; Genes; Genomes; India; Infections; Infertility; Lumpy skin disease; lumpy skin disease virus; Milk production; Morbidity; Mortality; New species; phylogenetic analysis; Phylogeny; RNA polymerase; Skin diseases; Sorbents; spillover; Vectors; Viruses; yak; Nepal; India; spillover; phylogenetic analysis; yak; cattle; lumpy skin disease virus; India
• ISSN: 2076-2607; 2076-2607
• DOI: 10.3390/microorganisms11122823

Lumpy skin disease (LSD), caused by the lumpy skin disease virus (LSDV), is a global concern that affects cattle and buffalo. Recently, the disease has been reported in new species such as the Indian Gazelle, Camel, Banteng, Gaur, and Giraffe from various parts of the world. This report provides an insight into the occurrence of LSD in Yak from Sikkim, a North-Eastern state of India. During the investigation, both cattle and yak exhibited typical clinical signs of LSD, including skin nodular lesions. The morbidity, mortality, and case fatality rates for cattle were 9.08%, 1.84%, and 20.24%, respectively. Similarly, the morbidity, mortality, and case fatality rates in yak were 7.57%, 1.24%, and 16.33%, respectively. The virus isolation and amplification of LSDV-specific genes confirmed the presence of LSDV in cattle, yak, and vectors. Further, demonstrated antibodies in randomly collected sera from naïve and unvaccinated cattle and yak using indirect Enzyme Linked Immuno-sorbent Assay (iELISA) and Serum Neutralisation test (SNT) from this region. Sequencing and phylogenetic analysis of , , and genes revealed that the virus isolated from both species was 100% identical to each other and also closely related to the field LSDV isolates circulating in the Indian subcontinent. The study highlighted the emergence of LSDV in unconventional hosts and underscored the need to include other bovine species in national disease control programs, encompassing disease surveillance initiatives.