U-shape short-range extrinsic connectivity organisation around the human central sulcus

• Published in: Brain Structure and Function Vol. 226; no. 1; pp. 179 - 193
• Main Authors: Pron, Alexandre, Deruelle, Christine, Coulon, Olivier
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2021; Springer Nature B.V; Springer Verlag
• Subjects: Algorithms; Asymmetry; Bioengineering; Biomedical and Life Sciences; Biomedicine; Brain; Cell Biology; Cognitive Sciences; Engineering Sciences; Fibers; Handedness; Imaging; Life Sciences; Magnetic resonance imaging; Motor ability; Neural networks; Neurology; Neurons and Cognition; Neurosciences; Original Article; Psychology and behavior; Signal and Image processing; Young adults; U-fibre; Diffusion MRI; Structural connectivity; Central sulcus
• ISSN: 1863-2653; 1863-2661; 1863-2661; 0340-2061
• DOI: 10.1007/s00429-020-02177-5

The central sulcus is probably one of the most studied folds in the human brain, owing to its clear relationship with primary sensory-motor functional areas. However, due to the difficulty of estimating the trajectories of the U-shape fibres from diffusion MRI, the short structural connectivity of this sulcus remains relatively unknown. In this context, we studied the spatial organization of these U-shape fibres along the central sulcus. Based on high quality diffusion MRI data of 100 right-handed subjects and state-of-the-art pre-processing pipeline, we first define a connectivity space that provides a comprehensive and continuous description of the short-range anatomical connectivity around the central sulcus at both the individual and group levels. We then infer the presence of five major U-shape fibre bundles at the group level in both hemispheres by applying unsupervised clustering in the connectivity space. We propose a quantitative investigation of their position and number of streamlines as a function of hemisphere, sex and functional scores such as handedness and manual dexterity. Main findings of this study are twofold: a description of U-shape short-range connectivity along the central sulcus at group level and the evidence of a significant relationship between the position of three hand related U-shape fibre bundles and the handedness score of subjects.