Alkaloids from Picrasma quassioides: An overview of their NMR data, biosynthetic pathways and pharmacological effects

• Published in: Phytochemistry (Oxford) Vol. 193; p. 112987
• Main Authors: Qian-wen, Chen, Xiao, Ye, Xiao-qian, Liu, Yao-hua, Liang, Wei-hong, Feng, Chun, Li, Zhi-min, Wang
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2022
• Subjects: Alkaloids; Alkaloids - pharmacology; biosynthesis; Biosynthetic Pathways; cardiovascular system; Magnetic Resonance Spectroscopy; Molecular Structure; NMR; nuclear magnetic resonance spectroscopy; Pharmacological effects; Picrasma; Picrasma quassioides; plant biochemistry; terpenoids; Picrasma quassioides; Alkaloids; NMR; Pharmacological effects
• ISSN: 0031-9422; 1873-3700; 1873-3700
• DOI: 10.1016/j.phytochem.2021.112987

Picrasma quassioides, a member of the Simaroubaceae family, is the subject of research in numerous pharmacological and chemical studies. This plant mainly contains alkaloids, quassinoids and terpenoids. These molecules exhibit various pharmacological benefits, such as anti-inflammatory, anticancer, and anti-viral effects, on the cardiovascular system. Alkaloids make up the majority of these molecules. This review describes 127 alkaloid substances from P. quassioides. These alkaloids can be divided into the following classes: β-carbolines, canthinones and alkaloid dimers. A compilation of their nuclear magnetic resonance spectroscopy data and possible biosynthetic pathways of these compounds and the pharmacological effects of P. quassioides are also included. [Display omitted] •The NMR spectral information of alkaloids from Picrasma quassioides is summarized.•The biosynthetic pathway of alkaloids in Picrasma quassioides is summarized.•The pharmacological effects and structure-activity relationship(SAR) of alkaloids in Picrasma quassioides is summarized.