Effects of calcitonin gene-related peptide on [3H]norepinephrine release in medulla oblongata of spontaneously hypertensive rats

We now describe the effects of calcitonin gene-related peptide (CGRP) on [3H]norepinephrine (NE) release in medulla oblongata of spontaneously hypertensive rats (SHR). CGRP inhibited stimulation-evoked [3H]NE release in a dose-dependent manner in Sprague-Dawley rats, although the basal release of [3...

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Published inEuropean journal of pharmacology Vol. 191; no. 1; p. 101
Main Authors Tsuda, K, Tsuda, S, Goldstein, M, Masuyama, Y
Format Journal Article
LanguageEnglish
Published Netherlands 20.11.1990
Subjects
Animals
Calcitonin Gene-Related Peptide - administration & dosage
Calcitonin Gene-Related Peptide - pharmacology
Calcitonin Gene-Related Peptide - physiology
Dose-Response Relationship, Drug
Hypertension - physiopathology
In Vitro Techniques
Male
Medulla Oblongata - drug effects
Medulla Oblongata - metabolism
Norepinephrine - metabolism
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Sympathetic Nervous System - physiopathology
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Abstract We now describe the effects of calcitonin gene-related peptide (CGRP) on [3H]norepinephrine (NE) release in medulla oblongata of spontaneously hypertensive rats (SHR). CGRP inhibited stimulation-evoked [3H]NE release in a dose-dependent manner in Sprague-Dawley rats, although the basal release of [3H]NE was not affected by the peptide. In SHR, the inhibitory effect of CGRP on stimulation-evoked [3H]NE release was significantly attenuated compared with Wistar Kyoto rats. These results suggest that CGRP might be involved in the regulation of central sympathetic nervous activity in hypertension.
AbstractList We now describe the effects of calcitonin gene-related peptide (CGRP) on [3H]norepinephrine (NE) release in medulla oblongata of spontaneously hypertensive rats (SHR). CGRP inhibited stimulation-evoked [3H]NE release in a dose-dependent manner in Sprague-Dawley rats, although the basal release of [3H]NE was not affected by the peptide. In SHR, the inhibitory effect of CGRP on stimulation-evoked [3H]NE release was significantly attenuated compared with Wistar Kyoto rats. These results suggest that CGRP might be involved in the regulation of central sympathetic nervous activity in hypertension.
Author Tsuda, K
Tsuda, S
Masuyama, Y
Goldstein, M
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  fullname: Masuyama, Y
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Snippet We now describe the effects of calcitonin gene-related peptide (CGRP) on [3H]norepinephrine (NE) release in medulla oblongata of spontaneously hypertensive...
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StartPage 101
SubjectTerms Animals
Calcitonin Gene-Related Peptide - administration & dosage
Calcitonin Gene-Related Peptide - pharmacology
Calcitonin Gene-Related Peptide - physiology
Dose-Response Relationship, Drug
Hypertension - physiopathology
In Vitro Techniques
Male
Medulla Oblongata - drug effects
Medulla Oblongata - metabolism
Norepinephrine - metabolism
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Sympathetic Nervous System - physiopathology
Title Effects of calcitonin gene-related peptide on [3H]norepinephrine release in medulla oblongata of spontaneously hypertensive rats
URI https://www.ncbi.nlm.nih.gov/pubmed/2092996
Volume 191
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