Effects of calcitonin gene-related peptide on [3H]norepinephrine release in medulla oblongata of spontaneously hypertensive rats

We now describe the effects of calcitonin gene-related peptide (CGRP) on [3H]norepinephrine (NE) release in medulla oblongata of spontaneously hypertensive rats (SHR). CGRP inhibited stimulation-evoked [3H]NE release in a dose-dependent manner in Sprague-Dawley rats, although the basal release of [3...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 191; no. 1; p. 101
Main Authors Tsuda, K, Tsuda, S, Goldstein, M, Masuyama, Y
Format Journal Article
LanguageEnglish
Published Netherlands 20.11.1990
Subjects
Animals
Calcitonin Gene-Related Peptide - administration & dosage
Calcitonin Gene-Related Peptide - pharmacology
Calcitonin Gene-Related Peptide - physiology
Dose-Response Relationship, Drug
Hypertension - physiopathology
In Vitro Techniques
Male
Medulla Oblongata - drug effects
Medulla Oblongata - metabolism
Norepinephrine - metabolism
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Sympathetic Nervous System - physiopathology
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Summary:We now describe the effects of calcitonin gene-related peptide (CGRP) on [3H]norepinephrine (NE) release in medulla oblongata of spontaneously hypertensive rats (SHR). CGRP inhibited stimulation-evoked [3H]NE release in a dose-dependent manner in Sprague-Dawley rats, although the basal release of [3H]NE was not affected by the peptide. In SHR, the inhibitory effect of CGRP on stimulation-evoked [3H]NE release was significantly attenuated compared with Wistar Kyoto rats. These results suggest that CGRP might be involved in the regulation of central sympathetic nervous activity in hypertension.
ISSN:0014-2999
DOI:10.1016/0014-2999(90)94102-4