Comparison of Neovascular Lesion Area Measurements From Different Swept-Source OCT Angiographic Scan Patterns in Age-Related Macular Degeneration

• Published in: Investigative ophthalmology & visual science Vol. 58; no. 12; pp. 5098 - 5104
• Main Authors: Zheng, Fang, Zhang, Qinqin, Motulsky, Elie H, de Oliveira Dias, João Rafael, Chen, Chieh-Li, Chu, Zhongdi, Miller, Andrew R, Feuer, William, Gregori, Giovanni, Kubach, Sophie, Durbin, Mary K, Wang, Ruikang K, Rosenfeld, Philip J
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 01.10.2017
• Subjects: Aged; Aged, 80 and over; Choroid - blood supply; Choroidal Neovascularization - diagnosis; Ciliary Arteries - pathology; Computed Tomography Angiography; Female; Humans; Male; Middle Aged; Retina; Retinal Vessels - pathology; Tomography, Optical Coherence - methods; Wet Macular Degeneration - diagnosis
• ISSN: 1552-5783; 0146-0404; 1552-5783
• DOI: 10.1167/iovs.17-22506

We compared area measurements for the same neovascular lesions imaged using swept source optical coherence tomography angiography (SS-OCTA) and enlarging scan patterns. Patients with neovascular age-related macular degeneration were imaged using a 100-kHz SS-OCTA instrument (PLEX Elite 9000). The scanning protocols included the 3 × 3, 6 × 6, 9 × 9, and 12 × 12 mm fields of view. Two groups were studied. Group 1 included small lesions contained within the 3 \( \times \) 3 mm scan, and Group 2 included larger lesions that were fully contained within the 6 \( \times \) 6 mm scan. A total of 30 eyes of 26 patients were enrolled in Group 1 and 30 eyes of 25 patients were enrolled in Group 2. In Group 1, the automated mean lesion area measurements were 1.11 (SD = 0.78), 1.14 (SD = 0.80), and 1.27 (SD = 0.82) mm2 for the 3 \( \times \) 3, 6 \( \times \) 6, and 12 \( \times \) 12 mm scans, respectively (ANOVA P < 0.001; post hoc comparisons, P = 0.184, 3 \( \times \) 3 vs. 6 \( \times \) 6 mm; P < 0.001 for the other two pairs). In Group 2, the automated mean lesion area measurements were 5.43 (SD = 2.56), 5.53 (SD = 2.48), and 5.49 (SD = 2.65) mm2 for the 6 \( \times \) 6, 9 \( \times \) 9, and 12 \( \times \) 12 mm scans, respectively (ANOVA P = 0.435; post-hoc comparisons, P = 0.062, 6 \( \times \) 6 vs. 9 \( \times \) 9 mm; P = 0.553, 6 \( \times \) 6 vs. 12 \( \times \) 12 mm; P = 0.654, 9 \( \times \) 9 vs. 12 \( \times \) 12 mm). The similarity in lesion area measurements across different scan patterns suggests that SS-OCTA imaging can be used to follow quantitatively the enlargement of choroidal neovascularization as the disease progresses.