Connection between inflammation and carcinogenesis in gastrointestinal tract: Focus on TGF-β signaling

Inflammation is a primary defense process against various extracellular stimuli,such as viruses,pathogens,foods,and environmental pollutants.When cells respond to stimuli for short periods of time,it results in acute or physiological inflammation.However,if the stimulation is sustained for longer ti...

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Published inWorld journal of gastroenterology : WJG Vol. 16; no. 17; pp. 2080 - 2093
Main Authors Hong, Suntaek, Lee, Ho-Jae, Kim, Seong Jin, Hahm, Ki-Baik
Format Journal Article
LanguageEnglish
Published United States Baishideng 07.05.2010
Subjects
Animals
Colorectal Neoplasms - etiology
Esophageal Neoplasms - etiology
Esophagitis, Peptic - complications
Gastritis, Atrophic - complications
Gastroenteritis - complications
Gastroenteritis - physiopathology
Gastrointestinal Neoplasms - drug therapy
Gastrointestinal Neoplasms - etiology
Gastrointestinal Neoplasms - physiopathology
Homeostasis
Humans
Inflammation Mediators - physiology
Inflammatory Bowel Diseases - complications
Ligands
Pancreatic Neoplasms - etiology
Pancreatitis, Chronic - complications
Signal Transduction - drug effects
Stomach Neoplasms - etiology
Topic Highlight
Transforming Growth Factor beta - antagonists & inhibitors
Transforming Growth Factor beta - physiology
Inflammation
Gastrointestinal tract
Carcinogenesis
Transforming growth factor-β
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Summary:Inflammation is a primary defense process against various extracellular stimuli,such as viruses,pathogens,foods,and environmental pollutants.When cells respond to stimuli for short periods of time,it results in acute or physiological inflammation.However,if the stimulation is sustained for longer time or a pathological state occurs,it is known as chronic or pathological inflammation.Several studies have shown that tumorigenesis in the gastrointestinal (GI) tract is closely associated with chronic inflammati...
Bibliography:14-1219/R
R57
Transforming growth factor-β
Inflammation
Gastrointestinal tract
Inflammation; Carcinogenesis; Transforming growth factor-β; Gastrointestinal tract
Carcinogenesis
Author contributions: Hong S wrote the manuscript; Lee HJ contributed to article processing; Kim SJ mentored all the research regarding TGF-β; Hahm KB organized, revised and orchestrated the manuscript.
Correspondence to: Ki-Baik Hahm, MD, PhD, Laboratory of Translational Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, Incheon 406-840, South Korea. hahmkb@gachon.ac.kr
Telephone: +82-32-8996055 Fax: +82-32-8996054
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v16.i17.2080