Conjugated linoleic acid is a growth factor for rats as shown by enhanced weight gain and improved feed efficiency

We studied the effect of conjugated linoleic acid (CLA) on rat development and growth. Primigravid female Fischer rats were fed control or CLA-supplemented (0.25% or 0.5% CLA) diets during gestation and/or lactation. Conjugated linoleic acid was incorporated into milk fat and tissue lipids proportio...

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Bibliographic Details
Published inThe Journal of nutrition Vol. 124; no. 12; pp. 2344 - 2349
Main Authors CHIN, S. F, STORKSON, J. M, ALBRIGHT, K. J, COOK, M. E, PARIZA, M. W
Format Journal Article
LanguageEnglish
Published Bethesda, MD American Society for Nutritional Sciences 01.12.1994
American Institute of Nutrition
Subjects
Animals
Biological and medical sciences
Body Weight - drug effects
Diet
Eating - drug effects
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Growth - drug effects
Linoleic Acids, Conjugated - administration & dosage
Linoleic Acids, Conjugated - pharmacology
Male
Milk - chemistry
Nutrition
Pregnancy
Rats
Rodents
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Weaning
Weight
Embryonic development
Nutrition
Rat
Growth
Rodentia
Polyunsaturated fatty acid
Lipids
Supplemented diet
Postnatal development
Biological activity
Feeding
Linoleic acid
Vertebrata
Mammalia
Somatic growth
Conjugated compound
Growth factor
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Summary:We studied the effect of conjugated linoleic acid (CLA) on rat development and growth. Primigravid female Fischer rats were fed control or CLA-supplemented (0.25% or 0.5% CLA) diets during gestation and/or lactation. Conjugated linoleic acid was incorporated into milk fat and tissue lipids proportional to the level of CLA fed and the duration of CLA feeding. Conjugated linoleic acid was incorporated into fetal and neonatal tissues; it did not affect litter size nor induce apparent abnormalities. To the contrary, feeding CLA to the dams during gestation and lactation improved the postnatal body weight gain of pups (P < 0.05), measured on d 10 of lactation. Pups that continued to receive the CLA-supplemented diet after weaning had significantly greater body weight gain and improved feed efficiency relative to control animals (P < 0.05).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0022-3166
1541-6100
DOI:10.1093/jn/124.12.2344