Association of selected adipokines with vitamin D deficiency in children with inflammatory bowel disease

• Published in: BMC pediatrics Vol. 24; no. 1; pp. 1 - 9
• Main Authors: Geryk, Milos, Kucerova, Veronika, Velganova-Veghova, Maria, Foltenova, Hana, Bouchalova, Katerina, Karasek, David, Radvansky, Martin, Karaskova, Eva
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 03.07.2024; BioMed Central; BMC
• Subjects: Adalimumab; Adipocyte fatty acid binding protein; Adiponectin; Age; Alfacalcidol; Analysis; Antibodies; Binding proteins; Body fat; Body mass index; Calcifediol; Children; Crohns disease; Cytokines; Demographic aspects; Development and progression; Fatty acids; Gastrointestinal diseases; Health aspects; Immunoassay; Immunomodulators; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Laboratories; Medical equipment and supplies industry; Medical research; Medical test kit industry; Medicine; Medicine, Experimental; Nesfatin-1; Pathogenesis; Pediatrics; Protein binding; Proteins; Remission (Medicine); Resistin; Retinoids; Retinol-binding protein 4; Vitamin D; Vitamin D deficiency; Vitamin deficiency; Czech Republic; Germany; Switzerland
• ISSN: 1471-2431; 1471-2431
• DOI: 10.1186/s12887-024-04890-0

Background Adipose tissue is significantly involved in inflammatory bowel disease (IBD). Vitamin D can affect both adipogenesis and inflammation. The aim of this study was to compare the production of selected adipokines, potentially involved in the pathogenesis of IBD - adiponectin, resistin, retinol binding protein 4 (RBP-4), adipocyte fatty acid binding protein and nesfatin-1 in children with IBD according to the presence of 25-hydroxyvitamin D (25(OH)D) deficiency. Methods The study was conducted as a case-control study in pediatric patients with IBD and healthy children of the same sex and age. In addition to adipokines and 25(OH)D, anthropometric parameters, markers of inflammation and disease activity were assessed in all participants. Results Children with IBD had significantly higher resistin levels regardless of 25(OH)D levels. IBD patients with 25(OH)D deficiency only had significantly lower RBP-4 compared to healthy controls and also compared to IBD patients without 25(OH)D deficiency. No other significant differences in adipokines were found in children with IBD with or without 25(OH)D deficiency. 25(OH)D levels in IBD patients corelated with RBP-4 only, and did not correlate with other adipokines. Conclusions Whether the lower RBP-4 levels in the 25(OH)D-deficient group of IBD patients directly reflect vitamin D deficiency remains uncertain. The production of other adipokines does not appear to be directly related to vitamin D deficiency. Keywords: Inflammatory bowel disease, Adiponectin, Resistin, Retinol-binding protein 4, Adipocyte fatty acid binding protein, Nesfatin-1, 25-hydroxyvitamin D