Secondary Neoplasms in Children with Hodgkin's Lymphoma Receiving C-MOPP and Radiotherapy: Presentation of Four Cases

• Published in: Turkish journal of haematology Vol. 33; no. 1; pp. 66 - 70
• Main Authors: Gözdaşoğlu, Sevgi, Pamir, Ali, Ünal, Emel, Gökçora, İsmail Haluk, Uluoğlu, Ömer, Ceyhan, Koray, Deda, Haluk, Işıkman, Erdoğan, Yavuz, Gülsan, Taçyıldız, Nurdan, Çavdar, Ayhan
• Format: Journal Article
• Language: English
• Published: Turkey Galenos Publishing 05.03.2016; Galenos Publishing House
• Subjects: Adenoma - etiology; Adolescent; Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Breast Neoplasms - etiology; Carcinoma, Ductal, Breast - etiology; Carcinoma, Papillary - etiology; Case Report; chemoradiotherapy; Chemoradiotherapy - adverse effects; Child; Cyclophosphamide - administration & dosage; Cyclophosphamide - adverse effects; Fatal Outcome; Female; Fibrosarcoma - etiology; Hodgkin Disease - therapy; hodgkin's lymphoma; Humans; Hypopharyngeal Neoplasms - etiology; Incidence; Male; Meningeal Neoplasms - etiology; Meningioma - etiology; Neoplasms, Radiation-Induced - epidemiology; Neoplasms, Radiation-Induced - etiology; Neoplasms, Radiation-Induced - therapy; Neoplasms, Second Primary - chemically induced; Neoplasms, Second Primary - epidemiology; Neoplasms, Second Primary - etiology; Neurilemmoma - etiology; Prednisone - administration & dosage; Prednisone - adverse effects; Procarbazine - administration & dosage; Procarbazine - adverse effects; Recurrence; Salvage Therapy - adverse effects; secondary neoplasms; Thyroid Neoplasms - etiology; Thyroid Nodule - etiology; Vincristine - administration & dosage; Vincristine - adverse effects
• ISSN: 1300-7777; 1308-5263
• DOI: 10.4274/tjh.2015.0027

Patients who survive Hodgkin lymphoma (HL) are at increased risk of secondary neoplasms (SNs). A wide variety of SNs have been reported, including leukemias, non-Hodgkin's lymphomas, and solid tumors, specifically breast and thyroid cancers. Herein we report subsequent neoplasms in four patients with HL receiving chemoradiotherapy. It is interesting that three SNs, fibrosarcoma, thyroid carcinoma, and retrobulbar meningioma, were observed in the radiation area in one of our patients. A hypopharyngeal epithelioid malignant peripheral nerve sheath tumor as an unusual secondary malignant neoplasm developed in another patient, while a benign thyroid nodule and invasive ductal breast carcinoma were observed at different times in the female patient. Follicular adenoma of the thyroid gland developed in one of our patients.