Inflammation and immunosuppression in severe acute pancreatitis

Acute pancreatitis(AP) is a common disease,which usually exists in its mild form.However,in a fifth of cases,the disease is severe,with local pancreatic complications or systemic organ dysfunction or both.Because the development of organ failure is the major cause of death in AP,early identification...

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Published inWorld journal of gastroenterology : WJG Vol. 16; no. 23; pp. 2867 - 2872
Main Authors Kylänpää, Marja-Leena, Repo, Heikki, Puolakkainen, Pauli Antero
Format Journal Article
LanguageEnglish
Published United States Department of Surgery, University of Helsinki, PL 340, 00029 HUS,Helsinki, Finland%Department of Bacteriology and Immunology,Haartman Institute, University of Helsinki, PL 340, 00029 HUS,Helsinki, Finland 21.06.2010
Baishideng
Subjects
Acute Disease
Blood Coagulation
Cytokines - biosynthesis
Humans
Immune Tolerance
Inflammation - blood
Inflammation - immunology
Inflammation - pathology
Inflammation Mediators - metabolism
Multiple Organ Failure - etiology
Pancreatitis - complications
Pancreatitis - immunology
Pancreatitis - pathology
Pancreatitis - therapy
Prognosis
Review
Sepsis - immunology
Sepsis - pathology
Inflammatory response
Immunosuppression
Acute pancreatitis
organ failure
Coagulation
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ISSN1007-9327
2219-2840
2219-2840
DOI10.3748/wjg.v16.i23.2867

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Summary:Acute pancreatitis(AP) is a common disease,which usually exists in its mild form.However,in a fifth of cases,the disease is severe,with local pancreatic complications or systemic organ dysfunction or both.Because the development of organ failure is the major cause of death in AP,early identification of patients likely to develop organ failure is important.AP is initiated by intracellular activation of pancreatic proenzymes and autodigestion of the pancreas.Destruction of the pancreatic parenchyma first indu...
Bibliography:Organ failure
Acute pancreatitis; Organ failure; Inflammatory response; Immunosuppression; Coagulation
Immunosuppression
Acute pancreatitis
R576
14-1219/R
Coagulation
Inflammatory response
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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Author contributions: Kylänpää ML, Repo H and Puolakkainen PA contributed equally to this work.
Correspondence to: Marja-Leena Kylänpää, MD, PhD, Department of Surgery, University of Helsinki, Haartmanninkatu 4, PL 340, 00029 HUS, Helsinki, Finland. leena.kylanpaa@hus.fi
Telephone: +358-9-4711 Fax: +358-9-47174675
ISSN:1007-9327
2219-2840
2219-2840
DOI:10.3748/wjg.v16.i23.2867