Polycystins and primary cilia: primers for cell cycle progression

• Published in: Annual review of physiology Vol. 71; p. 83
• Main Author: Zhou, Jing
• Format: Journal Article
• Language: English
• Published: United States 01.01.2009
• Subjects: Animals; Calcium Signaling - physiology; Cell Cycle - physiology; Cilia - physiology; GTP-Binding Proteins - physiology; Humans; Mechanotransduction, Cellular - physiology; Polycystic Kidney Diseases - physiopathology; TRPP Cation Channels - physiology

Polycystins are a family of eight-transmembrane proteins united by sequence homology. The name stems from the identification of mutations in genes encoding polycystin-1 and -2 in polycystic kidney diseases. This review discusses recent topics in polycystin research, with a focus on the role of polyc...