Polycystins and primary cilia: primers for cell cycle progression

Polycystins are a family of eight-transmembrane proteins united by sequence homology. The name stems from the identification of mutations in genes encoding polycystin-1 and -2 in polycystic kidney diseases. This review discusses recent topics in polycystin research, with a focus on the role of polyc...

Full description

Saved in:
Bibliographic Details
Published inAnnual review of physiology Vol. 71; p. 83
Main Author Zhou, Jing
Format Journal Article
LanguageEnglish
Published United States 01.01.2009
Subjects
Animals
Calcium Signaling - physiology
Cell Cycle - physiology
Cilia - physiology
GTP-Binding Proteins - physiology
Humans
Mechanotransduction, Cellular - physiology
Polycystic Kidney Diseases - physiopathology
TRPP Cation Channels - physiology
Online AccessGet more information

Cover

More Information
Summary:Polycystins are a family of eight-transmembrane proteins united by sequence homology. The name stems from the identification of mutations in genes encoding polycystin-1 and -2 in polycystic kidney diseases. This review discusses recent topics in polycystin research, with a focus on the role of polycystin-1 and polycystin-2 in primary cilia and the cell cycle. Polycystins appear to play key roles during development, but a major question is their function in mature organs. Their roles in primary cilia, shear stress sensation, alteration of intracellular calcium, and planar cell polarity are examined. The third-hit hypothesis of polycystic kidney disease is discussed.
ISSN:1545-1585
DOI:10.1146/annurev.physiol.70.113006.100621