Polycystins and primary cilia: primers for cell cycle progression
Polycystins are a family of eight-transmembrane proteins united by sequence homology. The name stems from the identification of mutations in genes encoding polycystin-1 and -2 in polycystic kidney diseases. This review discusses recent topics in polycystin research, with a focus on the role of polyc...
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| Published in | Annual review of physiology Vol. 71; p. 83 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.01.2009
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| Online Access | Get more information |
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| Abstract | Polycystins are a family of eight-transmembrane proteins united by sequence homology. The name stems from the identification of mutations in genes encoding polycystin-1 and -2 in polycystic kidney diseases. This review discusses recent topics in polycystin research, with a focus on the role of polycystin-1 and polycystin-2 in primary cilia and the cell cycle. Polycystins appear to play key roles during development, but a major question is their function in mature organs. Their roles in primary cilia, shear stress sensation, alteration of intracellular calcium, and planar cell polarity are examined. The third-hit hypothesis of polycystic kidney disease is discussed. |
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| AbstractList | Polycystins are a family of eight-transmembrane proteins united by sequence homology. The name stems from the identification of mutations in genes encoding polycystin-1 and -2 in polycystic kidney diseases. This review discusses recent topics in polycystin research, with a focus on the role of polycystin-1 and polycystin-2 in primary cilia and the cell cycle. Polycystins appear to play key roles during development, but a major question is their function in mature organs. Their roles in primary cilia, shear stress sensation, alteration of intracellular calcium, and planar cell polarity are examined. The third-hit hypothesis of polycystic kidney disease is discussed. |
| Author | Zhou, Jing |
| Author_xml | – sequence: 1 givenname: Jing surname: Zhou fullname: Zhou, Jing email: zhou@rics.bwh.harvard.edu organization: Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA. zhou@rics.bwh.harvard.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19572811$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Animals Calcium Signaling - physiology Cell Cycle - physiology Cilia - physiology GTP-Binding Proteins - physiology Humans Mechanotransduction, Cellular - physiology Polycystic Kidney Diseases - physiopathology TRPP Cation Channels - physiology |
| Title | Polycystins and primary cilia: primers for cell cycle progression |
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