Formation, characterization, and fate of inhaled drug nanoparticles

Nanoparticles bring many benefits to pulmonary drug delivery applications, especially for systemic delivery and drugs with poor solubility. They have recently been explored in pressurized metered dose inhaler, nebulizer, and dry powder inhaler applications, mostly in polymeric forms. This article pr...

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Bibliographic Details
Published inAdvanced drug delivery reviews Vol. 63; no. 6; pp. 441 - 455
Main Authors Zhang, Jian, Wu, Libo, Chan, Hak-Kim, Watanabe, Wiwik
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 30.05.2011
Subjects
Administration, Inhalation
Animals
Chemistry, Pharmaceutical - methods
Clearance
Drug Delivery Systems - methods
Formation
Humans
In-vitro
In-vivo
Inhalation
Nanoparticle
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Solubility
Nanoparticle
In-vivo
In-vitro
Clearance
Performance
Formation
Inhalation
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Summary:Nanoparticles bring many benefits to pulmonary drug delivery applications, especially for systemic delivery and drugs with poor solubility. They have recently been explored in pressurized metered dose inhaler, nebulizer, and dry powder inhaler applications, mostly in polymeric forms. This article presents a review of processes that have been used to generate pure (non polymeric) drug nanoparticles, methods for characterizing the particles/formulations, their in-vitro and in-vivo performances, and the fate of inhaled nanoparticles. [Display omitted]
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ISSN:0169-409X
1872-8294
DOI:10.1016/j.addr.2010.11.002