Psoriasis and Genetics

Psoriasis is a common inflammatory skin disease caused by the interplay between multiple genetic and environmental risk factors. This review summarises recent progress in elucidating the genetic basis of psoriasis, particularly through large genome-wide association studies. We illustrate the power o...

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Published inActa dermato-venereologica Vol. 100; no. 3; pp. adv00030 - 65
Main Authors Dand, Nick, Mahil, Satveer K, Capon, Francesca, Smith, Catherine H, Simpson, Michael A, Barker, Jonathan N
Format Journal Article
LanguageEnglish
Published Sweden Society for Publication of Acta Dermato-Venereologica 01.01.2020
Medical Journals Sweden
Subjects
disease progression
Genetic Predisposition to Disease - genetics
genetics
Genome-Wide Association Study
Humans
Phenotype
precision medicine
psoriasis
Psoriasis - drug therapy
Psoriasis - genetics
Review
Translational Research, Biomedical
Treatment Outcome
precision medicine
genetics
disease progression
treatment outcome
psoriasis
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Summary:Psoriasis is a common inflammatory skin disease caused by the interplay between multiple genetic and environmental risk factors. This review summarises recent progress in elucidating the genetic basis of psoriasis, particularly through large genome-wide association studies. We illustrate the power of genetic analyses for disease stratification. Psoriasis can be stratified by phenotype (common plaque versus rare pustular variants), or by outcome (prognosis, comorbidities, response to treatment); recent progress has been made in delineating the genetic contribution in each of these areas. We also highlight how genetic data can directly inform the development of effective psoriasis treatments.
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SourceType-Scholarly Journals-1
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ISSN:1651-2057
0001-5555
1651-2057
DOI:10.2340/00015555-3384