Non-enzymatic reactions in biogenesis of fungal natural products

Fungi have long been regarded as abundant sources of natural products (NPs) exhibiting significant biological activities. Decades of studies on the biosynthesis of fungal NPs revealed that most of the biosynthetic steps are catalyzed by sophisticated enzymes encoded in biosynthetic gene clusters, wh...

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Bibliographic Details
Published inJournal of natural medicines Vol. 78; no. 3; pp. 467 - 473
Main Author Kishimoto, Shinji
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 01.06.2024
Springer Nature B.V
Subjects
Biological products
Biological Products - chemistry
Biological Products - metabolism
Biomedical and Life Sciences
Biomedicine
Complementary & Alternative Medicine
Fungi
Fungi - metabolism
Gene clusters
Medicinal Chemistry
Mini-Review
Multigene Family
Natural products
Pharmacology/Toxicology
Pharmacy
Plant Sciences
Diels–Alderase
Spontaneous reaction
Cyclopenase
Diastereomer
Azlactone
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Summary:Fungi have long been regarded as abundant sources of natural products (NPs) exhibiting significant biological activities. Decades of studies on the biosynthesis of fungal NPs revealed that most of the biosynthetic steps are catalyzed by sophisticated enzymes encoded in biosynthetic gene clusters, whereas some reactions proceed without enzymes. These non-enzymatic reactions complicate biosynthetic analysis of NPs and play important roles in diversifying the structure of the products. Therefore, knowledge on the non-enzymatic reactions is important for elucidating the biosynthetic mechanism. This review focuses on non-enzymatic reactions we recently encountered during biosynthetic studies of four types of NPs (viridicatins, Sch210972, lentopeptins, and lentofuranine). Graphical abstract
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1340-3443
1861-0293
DOI:10.1007/s11418-024-01797-z