Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects

• Published in: Diabetes technology & therapeutics Vol. 13; no. 4; p. 451
• Main Authors: Gupta, Jyoti, Felner, Eric I, Prausnitz, Mark R
• Format: Journal Article
• Language: English
• Published: United States 01.04.2011
• Subjects: Adolescent; Adult; Area Under Curve; Blood Glucose - metabolism; Child; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - metabolism; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - blood; Hypoglycemic Agents - pharmacokinetics; Injections, Intradermal; Injections, Subcutaneous; Insulin - administration & dosage; Insulin - analogs & derivatives; Insulin - blood; Insulin - pharmacokinetics; Insulin Lispro; Pilot Projects; Young Adult
• ISSN: 1557-8593
• DOI: 10.1089/dia.2010.0204

This study compared the pharmacokinetics, postprandial glycemic response, and pain associated with intradermal lispro insulin delivery using a microneedle with that of a conventional catheter. Five subjects with type 1 diabetes were administered a bolus infusion of lispro insulin using a 9-mm-long subcutaneous catheter (control treatment) and a 0.9-mm-long microneedle (study treatment), followed by consumption of a standardized meal. Blood samples were periodically assayed for plasma glucose and free insulin levels. Intradermal insulin infusion using microneedles reached peak insulin concentrations in approximately half the time and led to greater reduction in plasma glucose levels than subcutaneous catheters. Microneedles were also significantly less painful than the catheters. The rapid pharmacokinetics and minimally invasive nature of intradermal insulin infusion using microneedles provide significant potential for improved diabetes management.