Interactions of Typical and Atypical Enteropathogenic Escherichia coli Strains with the Calf Intestinal Mucosa Ex Vivo

Enteropathogenic Escherichia coli (EPEC) can be found in healthy and diarrheic cattle; however, little is known about the role of attaching and effacing (A/E) lesion formation in colonization of bovine intestinal mucosa by such strains. We show that typical and atypical EPEC induce A/E lesions on ca...

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Published inApplied and Environmental Microbiology Vol. 75; no. 18; pp. 5991 - 5995
Main Authors Girard, Francis, Dziva, Francis, Stevens, Mark P, Frankel, Gad
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.09.2009
American Society for Microbiology (ASM)
Subjects
Animals
Bacterial Adhesion
Cattle
Colonization
Diarrhea
E coli
Enteropathogenic Escherichia coli - pathogenicity
Escherichia coli
Escherichia coli Proteins - metabolism
In Vitro Techniques
Intestinal Mucosa - microbiology
Intestinal Mucosa - pathology
Microbiology
Phosphorylation
Public Health Microbiology
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Summary:Enteropathogenic Escherichia coli (EPEC) can be found in healthy and diarrheic cattle; however, little is known about the role of attaching and effacing (A/E) lesion formation in colonization of bovine intestinal mucosa by such strains. We show that typical and atypical EPEC induce A/E lesions on calf intestinal explants independently of Tir tyrosine phosphorylation and TccP. Our data support the existence of conserved Tir- and TccP-independent mechanisms of A/E lesion formation in a range of hosts and reinforce the zoonotic potential of EPEC in cattle.
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Corresponding author. Mailing address: Centre for Molecular Microbiology and Infection, Division of Cell & Molecular Biology, Flowers Building, Imperial College London, London SW7 2AZ, United Kingdom. Phone: 44 020 2594 525. Fax: 44 020 5794 3069. E-mail: g.frankel@imperial.ac.uk
ISSN:0099-2240
1098-5336
1098-6596
DOI:10.1128/AEM.01170-09