Efficacy of early treatment with infliximab in pediatric Crohn’s disease

AIM: To investigate the effectiveness of early infliximab use for induction and maintenance therapy in pediatric Crohn’s disease. METHODS: We performed a retrospective chart review of 36 patients with Crohn’s disease. Ten patients (group A) were treated with mesalamine after induction therapy with o...

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Published inWorld journal of gastroenterology : WJG Vol. 16; no. 14; pp. 1776 - 1781
Main Authors Lee, Jong Seung, Lee, Jee Hyun, Lee, Ji Hyuk, Lee, Hye Jin, Kim, Mi Jin, Lee, Hae Jeong, Choe, Yon Ho
Format Journal Article
LanguageEnglish
Published United States Department of Pediatrics,College of Medicine,Chung-Ang University Yongsan Hospital,Yongsan,Seoul 140-757,South Korea%Department of Pediatrics,Samsung Medical Center,Sungkyunkwan University School of Medicine,Gangnam,Seoul 135-710,South Korea 14.04.2010
Baishideng
Subjects
Adolescent
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal - therapeutic use
Azathioprine - administration & dosage
Brief
Child
Child, Preschool
Crohn Disease - drug therapy
Crohn Disease - prevention & control
Female
Humans
Infliximab
Korea
Male
Mesalamine - administration & dosage
Prednisolone - administration & dosage
Retrospective Studies
Secondary Prevention
Tumor Necrosis Factor-alpha - antagonists & inhibitors
Korea
Efficacy
Top-down treatment
Pediatric Crohn's disease
Relapse rate
Infliximab
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Summary:AIM: To investigate the effectiveness of early infliximab use for induction and maintenance therapy in pediatric Crohn’s disease. METHODS: We performed a retrospective chart review of 36 patients with Crohn’s disease. Ten patients (group A) were treated with mesalamine after induction therapy with oral prednisolone, and 13 patients (group B) were treated with azathioprine after induction therapy with oral prednisolone. Thirteen patients (group C) received infliximab and azathioprine for induction and mainte...
Bibliography:Infliximab
Pediatric Crohn’s disease
14-1219/R
R574
Efficacy
Top-down treatment
Efficacy; Infliximab; Pediatric Crohn’s disease; Relapse rate; Top-down treatment
Relapse rate
Correspondence to: Yon Ho Choe, MD, PhD, Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam, Seoul 135-710, South Korea. i101016@skku.edu
Author contributions: Lee JS and Choe YH designed the study and wrote the manuscript; Lee JS, Lee JH, Lee JH, Lee HJ, Kim MJ and Lee HJ contributed equally to this study and analyzed the data.
Telephone: +82-2-34103539 Fax: +82-2-34100043
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v16.i14.1776