A Comparative Analysis of the Efficacy of Bacterial Lysate versus Antibiotic Therapy in the Treatment of Experimental Peri-Implantitis in Rats

• Published in: Microorganisms (Basel) Vol. 12; no. 8; p. 1537
• Main Authors: Ancuţa, Diana Larisa, Alexandru, Diana Mihaela, Ţucureanu, Cătălin, Coman, Cristin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.07.2024; MDPI
• Subjects: antibiotic therapy; Antibiotics; Bacteria; Bacterial infections; bacterial lysate; Biofilms; Bone imaging; Bone implants; Bone loss; Comparative analysis; Dental implants; Disease management; Ethylenediaminetetraacetic acid; Gum disease; Health aspects; Health services; Hypotheses; immunological response; Immunology; Leukocytes; Lysates; Metronidazole; Microbiota; Oral hygiene; peri-implantitis treatment; R&D; Research & development; rodent model; Veterinary medicine; Romania; United States > US; Bucharest Romania; antibiotic therapy; peri-implantitis treatment; immunological response; rodent model; bacterial lysate
• ISSN: 2076-2607; 2076-2607
• DOI: 10.3390/microorganisms12081537

Peri-implantitis (PI) is a current concern whose understanding and resolution are ongoing. We aimed to evaluate in vivo a new treatment with antibacterial properties, based on bacterial lysates obtained from the strains of , , and This research was conducted on 30 rats with PI which were divided into three groups and treated with antibiotic and anti-inflammatory (AAi) drugs, bacterial lysates (BLs), and saline (C), respectively. The monitoring period included the clinical and paraclinical examination where hematological, immunological, imaging, and histopathological analysis were performed. No particular clinical signs were observed, but the radiological examination showed the loss of all implants in group C, in contrast to group BL which had the highest survival rate of devices. White cells showed a decrease from the PI period, as did the immunological analysis. Only IL-6 showed an increase in the AAi and BL groups. Histopathologically, the C group presented a high degree of bone destruction, and in the BL group, many attenuated inflammatory phenomena appeared compared to the AAi animals. Bacterial lysates have similar effects to antibiotic-based therapeutic regimens for PI, and their future use may help to improve the current therapeutic management of the disease.