Phosphatidylserine in atherosclerosis

• Published in: Current opinion in lipidology Vol. 27; no. 4; p. 414
• Main Authors: Darabi, Maryam, Kontush, Anatol
• Format: Journal Article
• Language: English
• Published: England 01.08.2016
• Subjects: Atherosclerosis - complications; Atherosclerosis - metabolism; Atherosclerosis - physiopathology; Blood Coagulation; Cholesterol - metabolism; Humans; Inflammation - complications; Phosphatidylserines - metabolism
• ISSN: 1473-6535
• DOI: 10.1097/mol.0000000000000298

It is now widely acknowledged that phosphatidylserine is a multifunctional bioactive lipid. In this review, we focus on the function of phosphatidylserine in modulating cholesterol metabolism, influencing inflammatory response and regulating coagulation system, and discuss promising phosphatidylserine-based therapeutic approaches and detection techniques in atherosclerosis. Phosphatidylserine has been suggested to play important roles in physiological processes, such as apoptosis, inflammation, and coagulation. Recent data demonstrate atheroprotective potential of phosphatidylserine, reflecting its capacity to inhibit inflammation, modulate coagulation, and enhance HDL functionality. Furthermore, modern lipidomic approaches have enabled the investigation of phosphatidylserine properties relevant to the lipid-based drug delivery and development of reconstituted HDL. Studies of phosphatidylserine in relation to atherosclerosis represent an area of opportunity. Additional research elucidating mechanisms underlying experimentally observed atheroprotective effects of phosphatidylserine is required to fully explore therapeutic potential of this naturally occurring phospholipid in cardiovascular disease.